Summary: The existence of a second IgG-binding protein, protein Sbi, in has been reported previously. Later data indicated that protein Sbi also bound another serum component. This component has now been affinity-purified on immobilized protein Sbi and identified as β-glycoprotein I (β-GPI), also known as apolipoprotein H. The minimal β-GPI-binding domain was identified by shotgun phage display and the binding was shown to be mediated by a region of 57 amino acids, clearly separated from the IgG-binding domain. It is also shown that protein Sbi, and thus the β-GPI-binding activity, is expressed on the staphylococcal cell surface at levels varying between strains.


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