Summary: 12 cannot grow on -lyxose, but a mutant was isolated which can utilize -lyxose as sole source of carbon and energy for growth. -Lyxose is transported into the bacteria by the -xylose permease. The mutant constitutively synthesizes a new isomerase which is not inducible in the parent strain under any of the conditions tested. This enzyme, whose native substrate appears to be -man-nose, fortuitously converts -lyxose into -xylulose. Its structural gene is located at around 85 min on the genetic map, away from other known isomerase genes. -Xylulose is subsequently catabolized by the enzymes of the normal -xylose metabolic pathway. -Mannose isomerase was partially purified and some of its properties were examined.


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