RNA Metabolism during Morphogenesis in Histoplasma capsulatum

SUMMARY: During the transition from the mycelial to the yeast form of the dimorphic fungus Histoplasma capsulatum, RNA synthesis decreased to 26.7% of the normal level for at least 4 h. There was a decrease in total RNA on the first day of mycelial → yeast transition. Starting on the second day, RNA synthesis in the mycelial → yeast transition phase resumed and this event was paralleled by the emergence of bud-like constrictions on hyphal tips.