SUMMARY A mutant- strain of , in which the B-sequence of sexual morphogenesis is constitutive, utilizes glucose in the production of cellular material with an efficiency of about 9% of that of wild-type mycelium. The production of ATP by mitochondria isolated from the mutant is equal to that of mitochondria of normal mycelium, however, and mitochondrial ATPase activity appears the same from mycelia of the two types. Other comparative studies show the mutant to achieve approximately the same yield on ethanol and glucose, whereas wild type grows considerably less on ethanol. The mutant is much more sensitive than wild type to temperature and to inhibition by Krebs-cycle intermediaries. Both mutant and wild type are sensitive to the phosphorylation-inhibiting agent, DCCD. The over-all effect is a partial uncoupling of energy-conserving from energy-yielding processes. It was not possible to determine if the agents responsible for uncoupling were solely mitochondrial or cytoplasmic.


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