1887

Abstract

Summary: Growing cultures of NRRL1477 hydroxylate progesterone at the 11α-, 17α- and 6β-positions. Hydroxylation at the 11α-position seems to be predominant. At pH 7.5, extracts of this organism catalysed the hydroxylation of progesterone to 11α-hydroxyprogesterone and 11α-hydroxyallopregnane-3,20-dione. Ethylenediamine tetracetate inhibited and 2-mercaptoethanol stimulated this hydroxylation. While hydroxylation of progesterone at the 11α-position was optimal at pH 7.5, hydroxylation at the 17α-position was optimal at pH 6.5. The effect of some compounds and metal salts was studied.

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/content/journal/micro/10.1099/00221287-77-2-465
1973-08-01
2019-12-14
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-77-2-465
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