1887

Abstract

SUMMARY: The production of staphylococcal α-toxin in a synthetic amino acid medium was stimulated by a factor from yeast autolysate which was identified as histidine by chromatographic methods. Addition of histidine to the medium gave an early appearance of α-toxin, while serine and glycine stimulated its production in the late growth phase. The stimulatory capacity of serine and glycine in relation to their function as precursors in the synthesis of histidine is discussed.

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1973-01-01
2024-04-28
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References

  1. Ames B. N., Garry B. 1959; Coordinate repression of the synthesis of four histidine biosynthetic enzymes by histidine. Proceedings of the National Academy of Sciences of the United States of America 45:1453
    [Google Scholar]
  2. Bernheimer A. W., Schwartz L. 1963; Isolation and composition of staphylococcal α-toxin. Journal of General Microbiology 30:455–468
    [Google Scholar]
  3. Braman J., Norlin G. 1951; A factor in yeast dialysate of significance in the formation of staphylococcus toxin. Acta pathologica et microbiologica scandinavica 29:127–131
    [Google Scholar]
  4. Buchanan J. M., Sonne J. C., Deluva A. M. 1948; Biological precursors of uric acid; role of lactate, glycine, and carbon dioxide as precursors of carbon chain and nitrogen atom 7 of uric acid. Journal of Biological Chemistry 173:81–98
    [Google Scholar]
  5. Elek S. D. 1959 Staphylococcus pyogenes and Its Relation to Disease p. 223 Edinburgh and London: E. and S. Livingstone;
    [Google Scholar]
  6. Fildes P., Richardson G. M., Knight B. C. J. G., Gladstone G. P. 1936; A nutrient mixture suitable for the growth of Staphylococcus aureus. British Journal of Experimental Pathology 17:481–484
    [Google Scholar]
  7. Gladstone G. P. 1937; The nutrition of Staphylococcus aureus: nitrogen requirements. British Journal of Experimental Pathology 18:322–333
    [Google Scholar]
  8. Gladstone G. P. 1938; The production of staphylococcal α-haemolysin in a chemically-defined medium. British Journal of Experimental Pathology 19:208–226
    [Google Scholar]
  9. Hendricks C. W., Altenbern R. A. 1968; Studies on the synthesis of staphylococcal alpha toxin. Canadian Journal of Microbiology 14:1277–1281
    [Google Scholar]
  10. Kabat E. A., Mayer M. M. 1964 Experimental Immunochemistry p. 149 Springfield, Illinois: Charles C. Thomas;
    [Google Scholar]
  11. Kapral F. A. 1966; Studies on the induction of Staph, aureus alpha-toxin. Bacteriological Proceedings M35:44
    [Google Scholar]
  12. Kloos W. E., Pattee P. A. 1965; A biochemical characterization of histidine-dependent mutants of Staphylococcus aureus. Journal of General Microbiology 39:185–194
    [Google Scholar]
  13. Knight B. C. J. G. 1937; The nutrition of Staphylococcus aureus: nicotinic acid and vitamin B1. Biochemical Journal 31:731–737
    [Google Scholar]
  14. Randerath K. 1966 Thin-layer Chromatography p. 115 New York and London: Academic Press;
    [Google Scholar]
  15. Shooter R. A., Wyatt H. V. 1955; Mineral requirements for growth of Staphylococcus pyogenes Effect of calcium and magnesium ions. British Journal of Experimental Pathology 36:341–350
    [Google Scholar]
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