SUMMARY: Urea and allantoin were accumulated by germinating spores of in the presence of xanthine, uric acid or allantoin. The concentration of endogenous allantoin was 5 to 10 times higher than that of urea. The specific activities of uricase and allantoicase were increased about nine- and fivefold respectively by uric acid and allantoin. No induction of allantoinase and ureidoglycolase was detected. Results may suggest that the different levels of purine degradative enzyme during induction might favour allantoin accumulation and prevent urea from attaining a toxic concentration.


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