1887

Abstract

SUMMARY: The effects of cloxacillin, fusidic acid, lincomycin, erythromycin and novobiocin on a strain of were examined. Morphological effects of antibiotic action were observed in the scanning electron microscope on samples taken from cultures continuously monitored photometrically.

Cloxacillin caused surface changes similar to those previously reported with ampicillin and gave an opacity trace indicating slow lysis of the cells. Fusidic acid, lincomycin and erythromycin all caused total collapse of many of the cells which was reflected by an abrupt lytic phase on the opacity trace. Novobiocin gradually inhibited growth and led to bizarre, atypically dividing bacteria.

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/content/journal/micro/10.1099/00221287-70-2-263
1972-04-01
2021-10-21
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References

  1. Brock T.D. 1967 In Antibiotics 1 p 651 Gottlieb D., Shaw P. D. Edited by Berlin and New York: Springer-Verlag;
    [Google Scholar]
  2. Elek S.D. 1959 Staphylococcus pyogenes p 37 Edinburgh: E. S. Livingstone;
    [Google Scholar]
  3. Greenwood D., O’Grady F. 1969a; Antibiotic-induced surface changes in micro-organisms demonstrated by scanning electron microscopy. science; New York: 1631076–1078
    [Google Scholar]
  4. Greenwood D., O’Grady F. 1969b; A comparison of the effects of ampicillin on Escherichia coli and Proteus mirabilis . Journal of Medical Microbiology 2:435–441
    [Google Scholar]
  5. Klainer A.S., Betsch C.J. 1970; scanning-beam electron microscopy of selected micro-organisms. Journal of Infectious Diseases 121:339–343
    [Google Scholar]
  6. Klainer A.S., Perkins R.L. 1970; Antibiotic-induced alterations in the surface morphology of bacterial cells: A scanning-beam electron microscopy study. Journal of Infectious Diseases 122:233–328
    [Google Scholar]
  7. O’Grady F., Greenwood D., Hammond B., Mackintosh I.P., Watson B.W. 1970; Effects of penicillins on enterobacteria in mechanical systems simulating conditions of bacterial growth in the urinary tract. Proceedings of Anglo-Soviet Symposium on Semi-synthetic Penicillins In the press
    [Google Scholar]
  8. Smith C.G., Dietz A., Sokolski W.T., Savage G.M. 1956; Streptonivicin, a new antibiotic. Antibiotics and Chemotherapy 6:135–142
    [Google Scholar]
  9. Watson B.W., Gauci C.L., Blache L., O’Grady F.W. 1969; A single turbidity cell for contin-ously monitoring the growth of bacteria. Physics in Medicine and Biology 14:555–558
    [Google Scholar]
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