SUMMARY: The effects of cloxacillin, fusidic acid, lincomycin, erythromycin and novobiocin on a strain of were examined. Morphological effects of antibiotic action were observed in the scanning electron microscope on samples taken from cultures continuously monitored photometrically.

Cloxacillin caused surface changes similar to those previously reported with ampicillin and gave an opacity trace indicating slow lysis of the cells. Fusidic acid, lincomycin and erythromycin all caused total collapse of many of the cells which was reflected by an abrupt lytic phase on the opacity trace. Novobiocin gradually inhibited growth and led to bizarre, atypically dividing bacteria.


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