1887

Abstract

Summary: The virulence of is known to depend on the presence and on the quality of smooth-type O side-chains in the lipopolysaccharide (LPS). We have studied the effect on virulence of O side-chain modifications −O factors and which correspond to acetyl or glucosyl side-branches or a change in the linkage between repeating oligosaccharide units of the LPS (). The LD50 values of sister strains with and without these factors did not differ significantly, nor could we detect selection during mouse passage for or against forms possessing a variable O factor except perhaps in the case of factor . These O side-chain modifications thus appear neutral in respect of virulence.

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1971-11-01
2022-01-25
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References

  1. Archer J. R., Rowley D. 1969; A quantitative comparison of the antigenic structure of a virulent and an avirulent strain of Salmonella typhimurium . Immunology 17:551–558
    [Google Scholar]
  2. Auzins I., Rowley D. 1963; Factors involved in the adherence of S. typhimurium C5 and mouse peritoneal macrophages. Australian Journal of Experimental Biology and Medical Science 41:539–546
    [Google Scholar]
  3. Bagdian G., Lüderitz O., Staub A. M. 1966; Immunochemical studies on Salmonella: XI Chemical modification correlated with conversion of group B Salmonella by bacteriophage 27. Annals of the New York Academy of Sciences 133:405–424
    [Google Scholar]
  4. Bagdian G., Mäkelä P. H. 1971; Antigenic conversion by phage 27.1. Mapping of the prophage attachment site on the bacterial chromosome. Virology in Press
    [Google Scholar]
  5. Felix A. 1952; The Vi antigen of Salmonella paratyphi B . Journal of Hygiene 50:550–557
    [Google Scholar]
  6. Hellerqvist C-G., Lindberg B., Svensson S., Holme T., Lindberg A. A. 1968; Structural studies on the O-specific side chains of the cell wall lipopolysaccharide from Salmonella typhimurium 395 ms . Carbohydrate Research 9:237–241
    [Google Scholar]
  7. Iseki S., Kashiwagi K. 1955; Induction of somatic antigen 1 by bacteriophage in Salmonella B group. Proceedings of the Japan Academy 31:558–563
    [Google Scholar]
  8. Iseki S., Sakai T. 1952; On a variant strain of Salmonella B group which lost V factor and Forssman antigen caused by the action of anti-V factor serum. Proceedings of the Japan Academy 28:374–379
    [Google Scholar]
  9. Jenkin C. R., Karnovsky M. L., Rowley D. 1967; Preparation of an artificial antigen and immunity to mouse typhoid. Immunology 13:361–372
    [Google Scholar]
  10. Jenkin C. R., Rowley D. 1965; Partial purification of the ‘protective’ antigen of Salmonella typhimurium and its distribution amongst various strains of bacteria. Australian Journal of Experimental Biology and Medical Science 43:65–78
    [Google Scholar]
  11. Kauffmann F. 1940; Zur Serologie des I-Antigens in der Salmonella-Gruppe. Acta pathologica et micro-biologica scandinavica 17:135–144
    [Google Scholar]
  12. Kauffmann F. 1966 The Bacteriology of Enterobacteriaceae Copenhagen: Munksgaard;
    [Google Scholar]
  13. Le Minor L., Le Minor S., Nicolle P. 1961; Conversion de cultures de Salmonella Schwarzengrund et Salmonella Bredeney, dépourvues de l’antigène 27, en cultures 27 positives par la lysogénisation. Annales de L’Institut Pasteur 101:571–589
    [Google Scholar]
  14. Mäkelä P. H. 1963; Hfr males in Salmonella abony . Genetics 48:423–429
    [Google Scholar]
  15. Mäkelä P. H. 1966; Genetic determination of the O antigens of Salmonella groups B (4, 5, 12) and C1 (6, 7). Journal of Bacteriology 91:1115–1125
    [Google Scholar]
  16. Mäkelä P. H., Mäkelä P. H. 1966; Salmonella antigen 12 2: Genetics of form variation. Annales medicinae experimentalis et biologiae fenniaea 44:310–317
    [Google Scholar]
  17. Mäkelä P. H., Stocker B. A. D. 1969; Genetics of polysaccharide biosynthesis. Annual Review of Genetics 3:291–322
    [Google Scholar]
  18. Mantel N., Haenszel W. 1959; Statistical aspects of the analysis of data from retrospective studies of disease. Journal of the National Cancer Institute 22:719–748
    [Google Scholar]
  19. Reed L. G., Muench H. 1938; A simple method of estimating fifty per cent end points. American Journal of Hygiene 27:493–497
    [Google Scholar]
  20. Roantree R. J. 1967; Salmonella O antigen and virulence. Annual Review of Microbiology 21:443–466
    [Google Scholar]
  21. Sanderson K. E. 1970; Current linkage map of Salmonella typhimurium . Bacteriological Reviews 34:176–193
    [Google Scholar]
  22. Smith S. M., Stocker B. A. D. 1962; Colicinogeny and recombination. British Medical Bulletin 18:46–51
    [Google Scholar]
  23. Spaun J. 1952; A variant of Salmonella typhi (strain ‘ty2’) lacking antigen XII2with enhanced pathogenicity for mice. Acta pathologica et microbiologica scandinavica 31:86–91
    [Google Scholar]
  24. Valtonen V. V. 1970; Mouse virulence of Salmonella strains: The effect of different smooth-type O side-chains. Journal of General Microbiology 64:255–268
    [Google Scholar]
  25. Valtonen V. V., Sarvas M., Mäkelä P. H. 1971; The effect of T1 antigen on the virulence of Salmonella strains for mice. Journal of General Microbiology 69:99–106
    [Google Scholar]
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