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SUMMARY: A ribonuclease found in preparations of streptolysin S, unlike the strepto-coccal nucleases so far described, does not degrade DNA. It is only produced in significant amounts when RNA is present in the medium and is therefore an inducible enzyme. Unlike the previously described streptococcal enzymes it does not require divalent cations for activity. The molecular weight of the enzyme is about 14,000, its isoelectric point is 9.5 and it is highly heat-stable.
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