SUMMARY: The genetic properties of transformable (SR 5a) and non-transformable (SR30) streptomycin-resistant streptococci were examined. In mutant SR30, the very high resistance (VHR) phenotype appeared to be due to at least two factors; a high resistance (HR) mutation and an enhancing modifier gene. In mutant SR 5a, resistance was due to a single VHR mutation which is allelic to the HR mutation of mutant SR 30. The transfer of non-trans-formability (Ntr) by SR 30 DNA revealed that this factor is separable from the streptomycin resistance marker and the enhancing modifier. Results indicate co-transfer of Ntr with the HR marker.


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