1887

Abstract

SUMMARY: When staphylococci, resistant to 4 g. tetracycline/ml., were grown in nutrient media at subinhibitory levels of the drug, phenotypical resistance increased until the cocci grew with 160 g. tetracycline/ml. Resistance increased most rapidly at the highest concentration of tetracycline which did not significantly inhibit growth. Increase in resistance was also obtained by pre-incubation with -apo-5-oxy-tetracycline. Increase in resistance could be prevented by chloramphenicol and actinomycin D, but not by nalidixic acid. When a highly resistant culture was transferred to tetracycline-free medium, phenotypical resistance decreased gradually; after four transfers on nutrient agar it returned entirely to the original level.

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/content/journal/micro/10.1099/00221287-62-3-341
1970-08-01
2021-07-31
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