1887

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Volume 62, Issue 3

Inducible Resistance to Tetracycline in Free

Abstract

SUMMARY: When staphylococci, resistant to 4 g. tetracycline/ml., were grown in nutrient media at subinhibitory levels of the drug, phenotypical resistance increased until the cocci grew with 160 g. tetracycline/ml. Resistance increased most rapidly at the highest concentration of tetracycline which did not significantly inhibit growth. Increase in resistance was also obtained by pre-incubation with -apo-5-oxy-tetracycline. Increase in resistance could be prevented by chloramphenicol and actinomycin D, but not by nalidixic acid. When a highly resistant culture was transferred to tetracycline-free medium, phenotypical resistance decreased gradually; after four transfers on nutrient agar it returned entirely to the original level.

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© Society for General Microbiology 1970
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1970-08-01
2024-04-26
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Inducible Resistance to Tetracycline in Staphylococcus aureus
Microbiology 62, 341 (1970); https://doi.org/10.1099/00221287-62-3-341
/content/journal/micro/10.1099/00221287-62-3-341
/content/journal/micro/10.1099/00221287-62-3-341
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