SUMMARY: The mode of addition of the steroid substrate, 16α-hydroxycortexolone 16,17-acetonide, was shown to influence markedly the rate of enzymic conversion of the steroid as well as the form of growth of the fungal organism, in a mixed culture of (I-dehydrogenator) and (11β-hydroxylator). The effects observed were apparently related to the size and solubility of the steroid particles added in suspension or precipitated in the medium by addition of the steroid in any of several water-miscible non-aqueous solvents. The best rates of steroid conversion were observed when the mould grew in elongated pellets rather than in filamentous form.


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