1887

Abstract

SUMMARY: The effect of synthetic and naturally occurring polyamines on bacterial growth was studied. The tetra-amine spermine was the most potent anti-bacterial agent and showed maximal activity at high pH values. The anti-bacterial action of the triamines was dependent upon the number of the primary amino groups in the polyamine molecule and was maximal when it contained a -N(CH)N- moiety. Polyamines, in low concentrations, stimulated the incorporation of [C]uracil into the nucleic acids of growing bacteria, whereas higher concentrations were inhibitory. In contrast the incorporation of [C]valine into bacterial proteins was inhibited by polyamines, even in low concentrations.

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/content/journal/micro/10.1099/00221287-60-2-159
1970-02-01
2020-01-21
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-60-2-159
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