1887

Abstract

SUMMARY: The effect of synthetic and naturally occurring polyamines on bacterial growth was studied. The tetra-amine spermine was the most potent anti-bacterial agent and showed maximal activity at high pH values. The anti-bacterial action of the triamines was dependent upon the number of the primary amino groups in the polyamine molecule and was maximal when it contained a -N(CH)N- moiety. Polyamines, in low concentrations, stimulated the incorporation of [C]uracil into the nucleic acids of growing bacteria, whereas higher concentrations were inhibitory. In contrast the incorporation of [C]valine into bacterial proteins was inhibited by polyamines, even in low concentrations.

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/content/journal/micro/10.1099/00221287-60-2-159
1970-02-01
2021-10-21
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References

  1. Bachrach U., Eilon G. 1969; The effect of spermine and oxidized spermine on the enzymic degradation of DNA.. Biochimica et Biophysica Acta 179:494
    [Google Scholar]
  2. Caldarera C. M., Moruzzi M. S., Barbiroli B., Moruzzi G. 1968; Spermine and spermidine of the prostate gland of orchiectomized rats and their effect on RNA polymerase activity.. Biochemical and Biophysical Research Communications 33:266
    [Google Scholar]
  3. Davies J., Gilbert W., Gorini L. 1964; Streptomycin, suppression and the code.. Proceedings of the National Academy of Sciences of the United States of America 51:883
    [Google Scholar]
  4. Davies J., Gorini L., Davis B. D. 1965; Misreading of RNA codewords induced by aminoglycoside antibiotics.. Molecular Pharmacology 1:93
    [Google Scholar]
  5. Doerfler W., Zillig W., Fuchs E., Albers M. 1962; Untersuchungen zur Biosynthese der Proteine. V. Die Funktion von Nucleinsauren beim Einbau von Aminosauren in Proteine in einem zellfreien System aus Escherichia coli. . Hoppe-Seyler’s Zeitschrift fur Physiologische Chemie 330:96
    [Google Scholar]
  6. Dykstra W. G., Herbst E. J. 1965; Spermidine in regenerating liver: relation to rapid synthesis of ribonucleic acid.. Science, New York 149:428
    [Google Scholar]
  7. Edlin G., Broda P. 1968; Physiology and genetics of the ‘ribonucleic acid control’ locus in Escherichia coli. . Bacteriological Reviews 32:208
    [Google Scholar]
  8. Ezekiel D. H., Brockman H. 1968; Effect of spermine treatment on amino acid availability in amino acid starved Escherichia coli. . Journal of Molecular Biology 31:541
    [Google Scholar]
  9. Fox C. F., Gumport R. I., Weiss S. B. 1965; The enzymatic synthesis of ribonucleic acid. V. The interaction of ribonucleic acid polymerase with nucleic acids.. Journal of Biological Chemistry 240:2101
    [Google Scholar]
  10. Fox C. F., Robinson W. S., Haselkorn R., Weiss S. B. 1964; Enzymatic synthesis of ribonucleic acid. III. The ribonucleic acid-primed synthesis of ribonucleic acid with Micrococcus lysodeikticus ribonucleic acid polymerase.. Journal of Biological Chemistry 239:186
    [Google Scholar]
  11. Fox C. F., Weiss S. B. 1964; Enzymatic synthesis of ribonucleic acid. II. Properties of the deoxyribonucleic acid-primed reaction with Micrococcus lysodeikticus ribonucleic acid polymerase.. Journal of Biological Chemistry 239:175
    [Google Scholar]
  12. Fraser D., Mahler H. R. 1958; Effect of diamines on the protoplast infecting agent derived from T 2 bacteriophage.. Journal of the American Chemical Society 80:6456
    [Google Scholar]
  13. Friedman M. E., Bachrach U. 1966; Inhibition of protein synthesis by spermine in growing cells of Staphylococcus aureus. . Journal of Bacteriology 92:49
    [Google Scholar]
  14. Friedman S. M., Weinstein I. B. 1964; Lack of fidelity in the translation of synthetic polyribonucleotides.. Proceedings of the National Academy of Sciences of the United States of America 52:988
    [Google Scholar]
  15. Goldstein J. 1965; The effect of spermine on the accumulation of nucleic acids and protein in mammalian cells.. Experimental Cell Research 37:494
    [Google Scholar]
  16. Goldstein J. 1966; Resistance of RNA to thermal denaturation in the presence of polyamines.. Biochimica et Biophysica Acta 123:620
    [Google Scholar]
  17. Grossowicz N., Razin S., Rozansky R. 1955; Factors influencing the antibacterial action of spermine and spermidine on Staphylococcus aureus. . Journal of General Microbiology 13:436
    [Google Scholar]
  18. Guirard B. M., Snell E. E. 1964; Effect of polyamine structure on growth stimulation and spermine and spermidine content of lactic acid bacteria.. Journal of Bacteriology 88:72
    [Google Scholar]
  19. Hershko A., Amoz S., Mager J. 1961; Effect of polyamines and divalent metals on in vitro incorporation of amino acids into ribonucleoprotein particles.. Biochemical and Biophysical Research Communications 5:46
    [Google Scholar]
  20. Krakow J. S. 1963; Ribonucleic acid polymerase of Azotobacter vinelandii. III. Effect of polyamines.. Biochimica et Biophysica Acta 72:566
    [Google Scholar]
  21. Mager J., Benedict M., Artman M. 1962; A common site of action for polyamines and streptomycin.. Biochimica et Biophysica Acta 62:202
    [Google Scholar]
  22. Martin R. G., Ames B. N. 1962; The effect of polyamines and of poly U size on phenylalanine incorporation.. Proceedings of the National Academy of Sciences of the United States of America 48:2171
    [Google Scholar]
  23. Mills J., Dubin D. T. 1966; Some effects of spermine on Escherichia coli. . Molecular Pharmacology 2:311
    [Google Scholar]
  24. Moruzzi G., Barbiroli B., Caldarera C. M. 1968; Polyamines and nucleic acid metabolism in chick embryo. Incorporation of labelled precursors into nucleic acids of subcellular fractions and polyribosomal patterns.. Biochemical Journal 107:609
    [Google Scholar]
  25. O’Brien R. L., Olenick J. G., Hahn F. E. 1966; Reactions of quinine, chloroquinine and quinacrine with DNA and their effects on the DNA and RNA polymerase reactions.. Proceedings of the National Academy of Sciences of the United States of America 55:1511
    [Google Scholar]
  26. Ochoa M., Weinstein I. B. 1965; Spermine inhibition of polypeptide synthesis in a subcellular system derived from l-1210 mouse ascites leukemia.. Biochimica et Biophysica Acta 95:176
    [Google Scholar]
  27. Petersen E. E., ger H., Hagen U. 1968; The influence of spermidine on the reaction of RNA nucleotidyltransferase.. Biochimica et Biophysica Acta 161:325
    [Google Scholar]
  28. Pine M. J. 1964; New inhibitors of protein synthesis in Escherichia coli. . Bacteriological Proceedings103
    [Google Scholar]
  29. Raina A., Cohen S. S. 1966; Polyamines and RNA synthesis in a polyauxotrophic strain of E. coli. . Proceedings of the National Academy of Sciences of the United States of America 55:1587
    [Google Scholar]
  30. Razin S., Rozansky R. 1959; Mechanism of the antibacterial action of spermine.. Archives of Biochemistry and Biophysics 81:36
    [Google Scholar]
  31. Rozansky R., Bachrach U., Grossowicz N. 1954; Studies on the antibacterial action of spermine.. Journal of General Microbiology 10:11
    [Google Scholar]
  32. Rozansky R., Gurevitch J., Brzezinsky A., Eckerling B. 1949; Inhibition of the growth of Staphylococcus aureus by human semen.. Journal of Laboratory and Clinical Medicine 34:1526
    [Google Scholar]
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