SUMMARY: The effect of synthetic and naturally occurring polyamines on bacterial growth was studied. The tetra-amine spermine was the most potent anti-bacterial agent and showed maximal activity at high pH values. The anti-bacterial action of the triamines was dependent upon the number of the primary amino groups in the polyamine molecule and was maximal when it contained a -N(CH)N- moiety. Polyamines, in low concentrations, stimulated the incorporation of [C]uracil into the nucleic acids of growing bacteria, whereas higher concentrations were inhibitory. In contrast the incorporation of [C]valine into bacterial proteins was inhibited by polyamines, even in low concentrations.


Article metrics loading...

Loading full text...

Full text loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error