Full text loading...
SUMMARY: The effect of synthetic and naturally occurring polyamines on bacterial growth was studied. The tetra-amine spermine was the most potent anti-bacterial agent and showed maximal activity at high pH values. The anti-bacterial action of the triamines was dependent upon the number of the primary amino groups in the polyamine molecule and was maximal when it contained a -N(CH2)7N- moiety. Polyamines, in low concentrations, stimulated the incorporation of [14C]uracil into the nucleic acids of growing bacteria, whereas higher concentrations were inhibitory. In contrast the incorporation of [14C]valine into bacterial proteins was inhibited by polyamines, even in low concentrations.
Article metrics loading...
Full text loading...
References
Data & Media loading...