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SUMMARY: Lysogenic conversion of mycobacteria by phage Roy results in reciprocal changes in the phase and in the host cells. The temperate phage released after lysogenization differs from the converting phage in its host range. The lysogenic derivatives show marked changes in their colony morphology and in their sensitivity to phagolysis. Some, but not all, of the lysogenic bacteria have suffered losses in enzymic activity. An attempt is made to distinguish between host-determined and phage-determined variations.
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