SUMMARY: Enzymes elaborated by and by type A that disintegrated the organic component of human tooth dentine were compared with those attacking muscle collagen.

The potency of specific antisera to neutralize the enzymes disintegrating the organic component of dentine was determined by using as indicator finely divided decalcified dentine suspended in an agar gel.

By comparing the potency values of the sera with those obtained when muscle collagen preparations were used as indicators, it was evident that the organic component of dentine was attacked by the collagenases of type A ( antigen) and ( antigen) and probably by the antigen of . The antigen of type B had no action on decalcified dentine.


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