1887

Abstract

SUMMARY

Some aspects of the adsorption and release of Newcastle disease and Sendai viruses were studied in excised pieces of allantois of uniform size. About 40% of any saturating dose of either virus was adsorbed. The % adsorption was not influenced by treatment with neuraminidase. One-step growth curves indicated that the release process for both viruses was linear. The rate of release and the burst size were influenced by the composition of the medium used for maintaining the allantoic cells. Increases in the multiplicity of infection decreased the length of the latent period. Treatment of allantoic cells with suitable doses of actinomycin D or ultraviolet irradiation also affected the length of the latent period. These agents may increase the susceptibility of cells to infection by affecting DNA-directed mechanisms concerned in the control of nucleic acid synthesis.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-39-2-229
1965-05-01
2021-08-01
Loading full text...

Full text loading...

/deliver/fulltext/micro/39/2/mic-39-2-229.html?itemId=/content/journal/micro/10.1099/00221287-39-2-229&mimeType=html&fmt=ahah

References

  1. Barry R. D. 1961; The multiplication of influenza virus. I. The formation of incomplete virus. Virology 14:389
    [Google Scholar]
  2. Barry R. D. 1964; The effects of actinomycin D and ultraviolet irradiation on the production of fowl plague virus. Virology 24:563
    [Google Scholar]
  3. Barry R. D., Ives D. R., Cruickshank J. G. 1962; Participation of deoxyribo-nucleic acid in the multiplication of influenza virus. Nature, Lond 194:1139
    [Google Scholar]
  4. Bukrinskaya A. G., Zhdanov V. M. 1963; Shortening by actinomycin D of the latent period of multiplication of Sendai virus. Nature, Lond 200:920
    [Google Scholar]
  5. Burnet F. M., Stone J. D. 1947; The receptor destroying enzyme of V. cholerae. Aust. J. exp. Biol. med. Sci 25:227
    [Google Scholar]
  6. Cairns H. J. F. 1955; Multiplicity reactivation of influenza virus. J. Immun 75:326
    [Google Scholar]
  7. Cairns H. J. F. 1957; The asynchrony of infection by influenza virus. Virology 3:1
    [Google Scholar]
  8. Cairns H. J. F., Edney N. 1952; Quantitative aspects of influenza virus multiplication. 1. The production of ‘incomplete’ virus. J. Immun 69:155
    [Google Scholar]
  9. Cairns H. J. F., Fazekas de St Groth S. 1957; The number of allantoic cells in the chick embryo. J. Immun 78:191
    [Google Scholar]
  10. Cooper P. D. 1958; ‘Shortened latency’ as a result of multiple infection by vesicular stomatitis virus in chick cell culture. J. gen. Microbiol 19:340
    [Google Scholar]
  11. Dulbecco R., Vogt M. 1954; Plaque formation and isolation of pure lines with poliomyelitis virus. J. exp. Med 99:167
    [Google Scholar]
  12. Fazekas de St Groth S., Graham D. M. 1955; The production of incomplete virus particles among influenza strains. Chemical induction of the von Magnus phenomenon. Brit. J. exp. Path 36:205
    [Google Scholar]
  13. Fazekas de St Groth S., White D. O. 1958; An improved assay for the infectivity of influenza virus. J. Hyg., Comb 56:151
    [Google Scholar]
  14. Heller E. 1963; Enhancement of chikungunya virus replication and inhibition of interferon production by actinomycin D. Virology 21:652
    [Google Scholar]
  15. Isaacs A., Donald H. B. 1955; Particle counts of haemagglutinating viruses. J. gen. Microbiol 12:241
    [Google Scholar]
  16. Morgan J. F., Morton H. J., Parker R. C. 1950; Nutrition of animal cells in tissue culture. I. Initial studies on a synthetic medium. Proc. Soc. exp. Biol. Med 731
    [Google Scholar]
  17. Newton A., Dendy P. P., Smith C. L., Wildy P. 1962; A pool size problem associated with the use of tritiated thymidine. Nature, Lond 194:886
    [Google Scholar]
  18. Waterson A. P. 1962; Two kinds of myxovirus. Nature, Lond 193:1163
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-39-2-229
Loading
/content/journal/micro/10.1099/00221287-39-2-229
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error