1887

Abstract

Summary: Penicillinase-producing strains of isolated from human infections and kept under various conditions were plated out and fifty colonies from each plate tested for penicillin-sensitivity to determine the permanence of their resistance to penicillin.

Of 32 strains kept in Lemco broth and tested once, 5–12 months after isolation, two yielded only penicillin-sensitive colonies and fifteen others yielded a proportion of such.

Of six strains preserved by the gelatin-ascorbic acid drying process and kept for over a year, only one yielded penicillin-sensitive colonies.

Of six strains kept in Lemco broth with and without regular subculture and tested at intervals for 9 months, all gave rise to at least one penicillin-sensitive variant colony and more than half the colonies of one strain became penicillin-sensitive.

The natural tendency of these strains to yield penicillin-sensitive variant colonies was not appreciably accelerated by treatment with X-rays or by growing them with other organisms.

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/content/journal/micro/10.1099/00221287-3-2-274
1949-05-01
2022-01-17
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References

  1. Barber Mary. 1947a; Coagulase-positive staphylococci resistant to penicillin. J. Path. Bact. 59:373
    [Google Scholar]
  2. Barber Mary. 1947b.; Staphylococcal infection due to penicillin-resistant strains. Brit. med. J. ii:863
    [Google Scholar]
  3. Barber Mary, Rozwadowska-Dowzenko Mare. 1948; Infection by penicillin- resistant staphylococci. Lancet ii:641
    [Google Scholar]
  4. Bellamy W.D., Klimek J.W. 1948; Some properties of penicillin-resistant staphylococci. J. Bact. 55: 153
    [Google Scholar]
  5. Bennison W.H., Schwabacher H. 1948; Sensitization of penicillin-resistant bacteria. Lancet i:885
    [Google Scholar]
  6. Blair J.E., Carr Miriam. 1946; The action of penicillin on staphylococci. J. Immunol. 52:281
    [Google Scholar]
  7. Bondi A., Dietz Catherine. 1945; Penicillin-resistant staphylococci. Proc. Soc. exp. Biol., N.Y. 60,:55
    [Google Scholar]
  8. Demerec M. 1945; Production of staphylococcus strains resistant to various concentrations of penicillin. Proc. Nat. Acad. Sci. 31:215
    [Google Scholar]
  9. Gots J.S. 1945; Production of extracellular penicillin-inactivating substances associated with penicillin resistance in Staph, aureus. . Proc. Soc. exp. Biol., N. Y. 60:165
    [Google Scholar]
  10. Kirby W.M.M. 1944; Extraction of a highly potent penicillin-inactivator from penicillin-resistant staphylococci. Science 99:452
    [Google Scholar]
  11. Luria S.E. 1947; Recent advances in bacterial genetics. Bact. Rev. 11:1
    [Google Scholar]
  12. Spink W.W., Hall W.H., Ferris V. 1945; Clinical significance of staphylococci with natural or acquired resistance to the sulfonamides and to penicillin. J. Arner. med. Ass. 128:555
    [Google Scholar]
  13. Spink W.W., Ferris V. 1947; Penicillin-resistant staphylococci. Mechanisms involved in the development of resistance. J. Clin. Invest. 26:379
    [Google Scholar]
  14. Stamp lord. 1947; The preservation of bacteria by drying. J. gen. Microbiol. 1:251
    [Google Scholar]
  15. Voureka A. 1948; Sensitization of penicillin-resistant bacteria. Lancet 62:
    [Google Scholar]
  16. Wilson G.S., Atkinson J.D. 1945; Typing of staphylococci by the bacteriophage method. Lancet i:647
    [Google Scholar]
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