1887

Abstract

SUMMARY: The effect of thirty-seven different steroids on the growth of is reported. The effects varied from complete inhibition of growth to stimulation. Highly inhibitory compounds included androstan-3, 17-dione, testosterone, 11-deoxycorticosterone, progesterone and 7-dehydro-cholesterol. 17α-Hydroxypregnenolone was stimulatory but all other compounds with the 17α-hydroxyl group were inactive. Structural requirements for activity are discussed.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-28-3-437
1962-07-01
2022-01-24
Loading full text...

Full text loading...

/deliver/fulltext/micro/28/3/mic-28-3-437.html?itemId=/content/journal/micro/10.1099/00221287-28-3-437&mimeType=html&fmt=ahah

References

  1. Buetow D. E., Levedahl B. H. 1957; The effects of steroids on the growth of Euglena gracilis. Arch. Biochem. Biophys. 73:273
    [Google Scholar]
  2. Butler M., Knight B. C. J. G. 1960; Steroid growth requirements and steroid growth inhibitors of Mycoplasma. J. gen. Microbiol. 22:483
    [Google Scholar]
  3. Casas-Campillo C., Balandrano D., Galarza A. 1960; Steroids CLIX. Antimicrobial properties of 21,21-dimethoxyprogesterone analogues. J. Bact. 81:366
    [Google Scholar]
  4. Chattaway F. W., Townsley J. D., Barlow A. J. E. 1959; Effect of steroids and related compounds on the growth of dermatophytes. Nature, Lond. 184:1731
    [Google Scholar]
  5. Cremer G. 1955; Influence of adrenocortical hormones on dermatomycoses. Especially in Cushing’s syndrome. Dermatologica 111:285
    [Google Scholar]
  6. Edward D. G., ff. & Fitzerald W. A. 1951; Cholesterol in the growth of organisms of the pleuropneumonia group. J. gen. Microbiol. 5:576
    [Google Scholar]
  7. Jefferson W. E., Sisco G. 1959; The response of Aspergillus niger to added steroids. Fed. Proc. 18:253
    [Google Scholar]
  8. Lester G., Hechter O. 1959; The relationship of sodium, potassium and deoxycorticosterone in Neurospora crassa. Proc. not. Acad. Sci., Wash. 45:1792
    [Google Scholar]
  9. Lester G., Hechter O. 1961; Growth regulation in Penicillium puberulum by oestradiol-17β and deoxycorticosterone. J. Bact. 81:803
    [Google Scholar]
  10. Lester G., Stone D., Hechter O. 1958; The effects of deoxycorticosterone and other steroids on Neurospora crassa. Arch. Biochem. Biophys. 75:196
    [Google Scholar]
  11. Matkovics B. 1957; Über die Wirkung von Sterinen auf Microorganismen. Natur-wissenschaften 44:400
    [Google Scholar]
  12. Matkovics B., Sipos G. 1959; Effects of sterols on the growth of microorganisms. Acta Univ. Szeged. 5:25
    [Google Scholar]
  13. Matkovics B. 1960; Action of sterols on growth of microorganisms. Pharmazie 15:122
    [Google Scholar]
  14. Maxwell E. S., McGuire J. S., Tomkins G. N. 1960; Antibiotic effect of steroids on Saccharomyces fragilis and the isolation of a resistant mutant. J. Bact. 80:1
    [Google Scholar]
  15. Nelson L. M., McNiece K. J. 1959; Recurrent Cushing’s syndrome with Trichophyton rubrum infection. Arch. Derm. 80:700
    [Google Scholar]
  16. Reiss F. 1949; Steroid hormones; their fungistatic and genestatic effect on pathogenic fungi. Arch. Derm. Syph. (Berl.) 59:405
    [Google Scholar]
  17. Tarbet J. E., Oura M., Sternberg T. H. 1953; Microassay of antifungal properties of steroid hormones and other compounds. Mycologia 45:627
    [Google Scholar]
  18. van Wagendonk W. J., Conner R. L., Miller C. A., Rao M. R. R. 1953; Growth requirements of Paramecium aurelia var. 4: stock 51.7 sensitives and killers in axenie medium. Ann N.Y. Acad. Sci. 56:929
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-28-3-437
Loading
/content/journal/micro/10.1099/00221287-28-3-437
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error