1887

Abstract

SUMMARY: The infective component of the virus system of foot-and-mouth disease was concentrated and purified by ultracentrifugation and solvent extraction. Infective materials derived from ox, guinea-pig, mouse, chicken, goose and tissue culture were employed. The infective concentrates (D-fractions) and the separated smaller complement-fixing components (U-fractions) were characterized by infectivity, complement-fixing activity and nitrogen content. The D-fractions, of activity up to 10 ID50/g. N, represented less than 0·1% of the initial protein content. Electron micrographs of the D-fractions showed clusters and hexagonal arrays of 25 to 27 mμ ‘spherical’ particles of granular structure. These defined fractions of the virus system were used in a number of subsequent investigations.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-22-2-379
1960-04-01
2019-12-07
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-22-2-379
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error