SUMMARY: With a strain of as test organism, the potencies of compounds of the vitamin K group were estimated, and the results compared with those from animal assay techniques. The compounds showed in the main the same relative activity for the micro-organism as for higher animals, with two exceptions: 1:4-naphthoquinone was highly active for but is inactive for animals; phthiocol, which is active for animals, inhibited the response of to menaphthone, i.e. phthiocol acted as an anti-vitamin K for the micro-organism. Most of the compounds tested were toxic in the range 1-5 μg./ml.; vitamins K, K and a water soluble form of menaphthone (menaphthone bisulphite) were relatively less toxic.


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