1887

Abstract

Summary: With a strain of as test organism, the potencies of compounds of the vitamin K group were estimated, and the results compared with those from animal assay techniques. The compounds showed in the main the same relative activity for the micro-organism as for higher animals, with two exceptions: 1 : 4-naphthoquinone was highly active for but is inactive for animals; phthiocol, which is active for animals, inhibited the response of to menaphthone, i.e. phthiocol acted as an anti-vitamin K for the micro-organism. Most of the compounds tested were toxic in the range 1–5 g./ml.; vitamins K, K and a water soluble form of menaphthone (menaphthone bisulphite) were relatively less toxic.

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/content/journal/micro/10.1099/00221287-20-3-697
1959-06-01
2021-07-31
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