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SUMMARY: The tetanus toxin receptor in nervous tissue appears to be a ganglioside (mucolipid, strandin, containing: fatty acid, sphingosine, glucose, galactose, acetylgalactosamine, acetylneuraminic acid and amino acid (?) residues). The water- soluble ganglioside occurs in nervous tissue in the form of labile water-insoluble complexes with cerebrosides and sphingomyelins. The solubility of the complexes in water increases with increasing ganglioside content, but decreases when calcium is incorporated. Standing with ganglioside inactivates the toxin.
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