1887

Abstract

SUMMARY: The tetanus toxin receptor in nervous tissue appears to be a ganglioside (mucolipid, strandin, containing: fatty acid, sphingosine, glucose, galactose, acetylgalactosamine, acetylneuraminic acid and amino acid (?) residues). The water- soluble ganglioside occurs in nervous tissue in the form of labile water-insoluble complexes with cerebrosides and sphingomyelins. The solubility of the complexes in water increases with increasing ganglioside content, but decreases when calcium is incorporated. Standing with ganglioside inactivates the toxin.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-20-2-310
1959-04-01
2021-10-28
Loading full text...

Full text loading...

/deliver/fulltext/micro/20/2/mic-20-2-310.html?itemId=/content/journal/micro/10.1099/00221287-20-2-310&mimeType=html&fmt=ahah

References

  1. Bohm P., Dauber S., Baumeister L. 1954; Über Neuraminsäure, ihr Vorkommen und ihre Bestimmung in Serum. Klin. Wschr 32:289
    [Google Scholar]
  2. Filbes P. 1929; In Medical Research Council. A system of Bacteriology in Relation to Medicine 3298 London: H.M. Stationery Office;
    [Google Scholar]
  3. Folch J., Arsove S., Meath J. A. 1951; Isolation of brain strandin, a new type of large molecule tissue component. J. biol. Chem 191:819
    [Google Scholar]
  4. Folch-Pi J., LeBaron F. N. 1957; Chemical composition of the mammalian nervous system. In Metabolism of the Nervous System p. 67 Richter D. Ed London: Pergamon Press;
    [Google Scholar]
  5. Fulthorpe A. J. 1956; Adsorption of tetanus toxin by brain tissue. J. Hyg., Comb 54:315
    [Google Scholar]
  6. Gregory J. D., Craig L. C. 1948; Counter-current distribution of gramicidin. J. biol. Chem 172:839
    [Google Scholar]
  7. Klenk E. 1955; The pathological chemistry of the developing brain. In Bio-chemistry of the Developing Nervous System p. 397 New York: Academic Press Inc;
    [Google Scholar]
  8. Landsteiner K., Botteri A. 1906; Über Verbindungen von Tetanustoxin mit Lipoiden. IV. Zbl. Bakt. (Orig) 42:562
    [Google Scholar]
  9. LeBaron F. N., Folch J. 1957; Structure of brain tissue lipids. Physiol. Rev 37:539
    [Google Scholar]
  10. Rosenberg A., Chargaff E. 1958; A study of a mucolipide from ox brain. J. biol. Chem 232:1031
    [Google Scholar]
  11. Rosenberg A., Howe C., Chargaff E. 1956; Inhibition of influenza virus haemagglutination by a brain lipid fraction. Nature; Lond: 177234
    [Google Scholar]
  12. Svennerholm L. 1956; Composition of gangliosides from human brain. Nature; Lond: 177524
    [Google Scholar]
  13. Svennerholm L. 1957; Quantitative estimation of gangliosides in senile human brains. Acta Soc. Med. Uppsala 62:1
    [Google Scholar]
  14. Takaki T. 1908; Über Tetanusgift bindende Bestandteile des Gehirns. Beitr. chem. Physiol. Path 11:288
    [Google Scholar]
  15. van Heyningen W. E. 1959a; The fixation of tetanus toxin by nervous tissue. J. gen. Microbiol 20:291
    [Google Scholar]
  16. van Heyningen W. E. 1959b; Chemical assay of the tetanus toxin receptor in nervous tissue. J. gen. Microbiol 20:301
    [Google Scholar]
  17. Wright G. P. 1955; The neurotoxins of Clostridium botulinum and Clostridium tetani. Pharmacol. Rev 7:413
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-20-2-310
Loading
/content/journal/micro/10.1099/00221287-20-2-310
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error