Investigations on the size of inhibition zones in agar tube cultures of (Mayo) due to diffusion of streptomycin have confirmed the formula previously suggested. No significant deviation from expectations has been found over a temperature range of 27-40°, nor with variations of inoculum size from 2 x 10 to 5 x 10 organisms/ml. The theoretical basis of the formula has been further elucidated and the meaning of and clarified. These constants are determined by the necessity of absorbing a of antibiotic on the organisms to inhibit growth within the zone. To maintain this absorption a minimum inhibitory concentration must remain in the surrounding medium.


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