SUMMARY: The antigen found in acid extracts of some type-4 Group-A streptococci which is responsible for precipitation with specific antisera is resistant to digestion with trypsin and pepsin when in the cell. It becomes sensitive to these enzymes after extraction with boiling HCl. It is not an M antigen but resembles a T antigen although it, is more heat-stable at low pH values than the T antigen of most other types. Another precipitating antigen, common in freshly isolated type-4 strains but not restricted to them, is described and referred to as ‘B’. Its role as a blocking agent in inhibiting the formation of M antibody is discussed.


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