1887

Abstract

Summary: During passage of the influenza A strain CAM in eggs in the presence of anti-CAM serum, three true-breeding variants were isolated. The variants I, I and SP showed increasing resistance to inhibition by anti-CAM serum. The evidence indicated that virus population changed in the course of passage as a result of the appearance of successive variants capable of preferential survival in the experimental environment. The strains I and SP, unlike the parent strain CAM, were pathogenic for mice inoculated intranasally. The implications of these findings are discussed.

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/content/journal/micro/10.1099/00221287-17-1-25
1957-08-01
2022-01-20
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