1887

Abstract

The starvation survival response (SSR) of EGD is induced under glucose- or multiple-nutrient-, but not amino-acid limitation. 001–02% of the population remain viable even after 20 d and the survivors show a reduced cell size and increased cross-protection to several environmental stresses. The development of the SSR may therefore be important in survival in the food environment. The initiation, but not the maintenance, of the SSR involves both protein and cell wall biosynthesis. It is also likely that nutrients released from dead cells are recycled to allow survival of the remaining population. To define the molecular mechanisms involved in the initiation, maintenance and release from the SSR the role of known, and novel, components was examined. The well-characterized regulators SigB and PrfA are both required for the full SSR and effect stress resistance during growth and starvation. A transposon mutagenesis screen identified two novel loci with roles in the SSR and stress resistance. Characterization of the transposon insertion sites revealed a putative homologue of the gene from and a gene of unknown function. The potential individual and combined roles of the SSR components are discussed.

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2001-08-01
2019-10-15
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