1887

Abstract

Comparative analysis of the conjugative transposons Tn from and Tn from , and the CW459(M) element from , has revealed that these tetracycline-resistance elements are closely related. All three elements contain the (M) resistance gene and have sequence similarity throughout their central region. However, they have very different integration/excision modules. Instead of the and genes that are found in Tn, Tn has a large resolvase gene, . The element encodes the putative Int459 protein, which is a member of the integrase family of site-specific recombinases but is not closely related to Int from Tn. Based on these studies it is concluded that the clostridial elements have a modular genetic organization and were derived independently from distinct mobile genetic elements.

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2001-05-01
2021-07-25
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