1887

Abstract

Homologues of , encoding extremely hydrophobic proteins, were identified in the genomes of and . Allelic replacement mutagenesis demonstrated that the gene is not essential for growth in either organism, and the mutants showed no significant changes in growth rate or morphology. The mutant showed slightly reduced virulence in a mouse model of infection and an eightfold increase in bacitracin susceptibility. However, a mutant was highly attenuated in a mouse model of infection, and demonstrated an increase in susceptibility to bacitracin of up to 160000-fold. These observations are consistent with the previously proposed role of BacA protein as undecaprenol kinase.

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2000-07-01
2020-01-21
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