Mutant studies of phosphofructo-2-kinases do not reveal an essential role of fructose-2, 6-bisphosphate in the regulation of carbon fluxes in yeast cells

References

1. Arvanitidis A., Heinisch J. 1994; Studies on the function of yeast phosphofructokinase subunits by in vitro mutagenesis. J Biol Chem 269:8911–8918
   [Google Scholar]
2. Bartrons R., Van Schaftingen E., Vissers S., Hers H. G. 1982; Stimulation of yeast phosphofructokinase by fructose-2,6-bisphosphate. FEBS Lett 143:137–140
   [Google Scholar]
3. Bergmeyer H. U. 1974 Methods of Enzymatic Analysis. Weinheim: Verlag Chemie;
   [Google Scholar]
4. Boles E., Miosga T. 1995; A rapid and highly efficient method for PCR-based site-directed mutagenesis using only one new primer. Curr Genet 28:197–198
   [Google Scholar]
5. Boles E., Zimmermann F. K. 1993; Saccharomyces cerevisiae phosphoglucose isomerase and fructose bisphosphate aldolase can be functionally replaced by the corresponding enzymes of Escherichia coli and Drosophila melanogaster . Curr Genet 23:187–191
   [Google Scholar]
6. Boles E., Heinisch J., Zimmermann F. K. 1993; Different signals control the activation of glycolysis in the yeast Saccharomyces cerevisiae . Yeast 9:761–770
   [Google Scholar]
7. Boles E., Göhlmann H. W. H., Zimmermann F. K. 1996; Cloning of a second gene encoding 6-phosphofructo-2-kinase in yeast and characterization of mutant strains without fructose-2,6-bisphosphate. Mol Microbiol 20:65–76
   [Google Scholar]
8. Breitenbach-Schmitt I., Heinisch J., Schmitt H. D., Zimmermann F. K. 1984; Yeast mutants without phosphofructokinase activity can still perform glycolysis and alcoholic fermentation. Mol Gen Genet 195:530–535
   [Google Scholar]
9. Ciriacy M., Breitenbach I. 1979; Physiological effects of seven different blocks in glycolysis in Saccharomyces cerevisiae . J Bacteriol 139:152–160
   [Google Scholar]
10. Davies S. E. C., Brindle K. M. 1992; Effects of overexpression of phosphofructokinase on glycolysis in the yeast Saccharomyces cerevisiae . Biochemistry 31:4729–4735
    [Google Scholar]
11. Entian K.-D., Barnett J. A. 1992; Regulation of sugar utilization by Saccharomyces cerevisiae . Trends Biochem Sci 17:506–510
    [Google Scholar]
12. Fell D. A., Thomas S. 1995; Physiological control of flux: the requirement for multisite modulation. Biochem J 311:35–39
    [Google Scholar]
13. François J., Van Schaftingen E., Hers H. G. 1984; The mechanism by which glucose increases fructose-2,6-bisphosphate concentration in Saccharomyces cerevisiae . Eur J Biochem 145:187–193
    [Google Scholar]
14. Frančois J., Eraso P., Gancedo C. 1987; Changes in the concentrations of cAMP, fructose-2,6-bisphosphate and related metabolites and enzymes in Saccharomyces cerevisiae during growth on glucose. Eur J Biochem 164:369–373
    [Google Scholar]
15. François J., Villanueva M. E., Hers H. G. 1988; The control of glycogen metabolism in yeast. Eur J Biochem 174:551–559
    [Google Scholar]
16. Gancedo J. M., Gancedo C. 1971; Fructose-1,6-diphosphatase, phosphofructokinase and glucose-6-phosphate dehydrogenase from fermenting and non-fermenting yeast. Arch Microbiol 76:132–138
    [Google Scholar]
17. Gancedo J. M., Mazón M. J., Gancedo C. 1982; Kinetic differences between two interconvertible forms of fructose-1,6-bisphosphatase from Saccharomyces cerevisiae . Arch Biochem Biophys 218:478–482
    [Google Scholar]
18. Gietz R. D., Sugino A. 1988; New yeast –Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six base-pair restriction sites. Gene 74:527–534
    [Google Scholar]
19. Guthrie C., Fink E. R. 1991; Guide to yeast genetics and molecular biology. Methods Enzymol 194:1–933
    [Google Scholar]
20. Heinisch J. 1986; Isolation and characterization of the two structural genes coding for phosphofructokinase in yeast. Mol Gen Genet 202:75–82
    [Google Scholar]
21. Heinisch J., Ritzel R. G., von Borstel R. C., Aguilera A., Rodicio R., Zimmermann F. K. 1989; The phosphofructokinase genes of yeast evolved from two duplication events. Gene 78:309–321
    [Google Scholar]
22. Heinisch J. J., Boles E., Timpel C. 1996; A yeast phosphor-fructokinase insensitive to the allosteric activator fructose-2,6-bisphosphate. J Biol Chem 271:15928–15933
    [Google Scholar]
23. Hers H. G., Van Schaftingen E. 1982; Fructose-2,6-bisphosphate 2 years after its discovery. Biochem J 206:1–12
    [Google Scholar]
24. Keßler R., Eschrich K. 1996; Ser⁶⁴⁴ is important for catalytic activity but is not involved in cAMP-dependent phosphorylation of yeast 6-phosphofructo-2-kinase. FEBS Lett 395:225–227
    [Google Scholar]
25. Kretschmer M., Fraenkel D. G. 1991; Yeast 6-phosphofructo-2-kinase: sequence and mutant. Biochemistry 30:10663–10672
    [Google Scholar]
26. Kretschmer M., Tempest P., Fraenkel D. G. 1991; Identification and cloning of yeast phosphofructokinase 2. Eur J Biochem 197:367–372
    [Google Scholar]
27. Lederer B., Vissers S., Van Schaftingen E., Hers H. G. 1981; Fructose-2,6-bisphosphate in yeast. Biochem Biophys Res Commun 103:1281–1287
    [Google Scholar]
28. Lillie S. H., Pringle J. R. 1980; Reserve carbohydrate metabolism in Saccharomyces cerevisiae: responses to nutrient limitation. J Bacteriol 143:1384–1394
    [Google Scholar]
29. Marcus F., Rittenhouse J., Moberly L., Edelstein I., Hiller E., Rogers D. T. 1988; Yeast (Saccharomyces cerevisiae) fructose-1, 6-bisphosphatase. J Biol Chem 263:6058–6062
    [Google Scholar]
30. Müller S., Boles E., Zimmermann F. K. 1996; A two-hybrid system analysis shows interactions between 6-phosphofructo-1-kinase and 6-phosphofructo-2-kinase but not between other glycolytic enzymes of the yeast Saccharomyces cerevisiae . Eur J Biochem 236:626–631
    [Google Scholar]
31. Navas M. A., Gancedo J. M. 1996; The regulatory characteristics of yeast fructose-1,6-bisphosphatase confer only a small selective advantage. J Bacteriol 178:1809–1812
    [Google Scholar]
32. Navas M. A., Cerdán S., Gancedo J. M. 1993; Futile cycles in Saccharomyces cerevisiae strains expressing the gluconeogenic enzymes during growth on glucose. Proc Natl Acad Sci USA 90:1290–1294
    [Google Scholar]
33. Noda T., Hoffschulte H., Holzer H. 1984; Characterization of fructose-1,6-bisphosphatase from bakers’ yeast. J Biol Chem 259:7191–7197
    [Google Scholar]
34. Paravicini G., Kretschmer M. 1992; The yeast FBP26 gene codes for a fructose-2,6-bisphosphatase. Biochemistry 31:7126–7133
    [Google Scholar]
35. Sambrook J., Fritsch E. F., Maniatis T. 1989 Molecular Cloning: a Laboratory Manual 2nd edn Cold Spring Harbor, NY: Cold Spring Harbor Laboratory;
    [Google Scholar]
36. Schaaff I., Heinisch J., Zimmermann F. K. 1989; Over-production of glycolytic enzymes in yeast. Yeast 5:285–290
    [Google Scholar]
37. Schiestl R. H., Gietz R. D. 1989; High efficiency transformation of intact yeast cells by single stranded nucleic acids as carrier. Curr Genet 16:339–346
    [Google Scholar]
38. Thevelein J. M. 1991; Fermentable sugars and intracellular acidification as specific activators of the RAS-adenylate cyclase signalling pathway in yeast: the relationship to nutrient-induced cell cycle control. Mol Microbiol 5:1301–1307
    [Google Scholar]
39. Thomas S., Fell D. A. 1996; Design of metabolic control for large flux changes. J Theor Biol 182:285–298
    [Google Scholar]
40. Van Schaftingen E. 1987; Fructose-2,6-bisphosphate. Adv Enzymol Relat Areas Mol Biol 59:315–395
    [Google Scholar]
41. Van Schaftingen E., Lederer B., Bartrons R., Hers H. G. 1982; A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Eur J Biochem 129:191–195
    [Google Scholar]
42. Wilson R. B., Renault G., Jacquet M., Tatchell K. 1993; The pde2 gene of Saccharomyces cerevisiae is allelic to rca1 and encodes a phosphodiesterase which protects the cell from extracellular cAMP. FEBS Lett 325:191–195
    [Google Scholar]
43. Zamenhoff S. 1957; Preparation and assay of deoxyribonucleic acids from animal tissue. Methods Enzymol 3:696–704
    [Google Scholar]