1887

Abstract

Expression of the gene is regulated in part by the nutrients available to the cell, and is decreased in rich medium, in glucose minimal media enriched with amino acids, and in minimal medium with alternative carbon sources, such as acetate and succinate. When Lrp production is increased in a given medium, expression of its target genes is also increased. However, when the medium is changed from glucose to acetate, the response of the target genes is governed by many factors.

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/content/journal/micro/10.1099/00221287-143-6-2079
1997-06-01
2021-10-25
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References

  1. Ambartsoumian G., D’Ari R., Lin R. T., Newman E. B. 1994; Altered amino acid metabolism in lrp mutants of Escherichia coli K12 and their derivatives.. Microbiology 140:1737–1744
    [Google Scholar]
  2. Calvo J. M., Matthews R. G. 1994; Leucine-responsive regulatory protein - a global regulator of metabolism in Escherichia coli.. Microbiol Rev 58:466–498
    [Google Scholar]
  3. D’Ari R., Lin R. T., Newman E. B. 1993; The leucine-responsive regulatory protein: more than a regulator?. Trends Biochem Sci 18:260–263
    [Google Scholar]
  4. Ernsting B. R., Atkinson M. R., Ninfa A. J., Matthews R. G. 1992; Characterization of the regulon controlled by the leucine responsive regulatory protein in Escherichia coli.. J Bacteriol 174:1109–118
    [Google Scholar]
  5. Guzman L. M., Belin D., Carson M. J., Beckwith J. 1995; Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter.. J Bacteriol 177:4121–4130
    [Google Scholar]
  6. Lin R., D’Ari R., Newman E. B. 1990; The leucine regulon of Escherichia coli: a mutation in rblA alters expression of L-leucinedependent metabolic operons.. J Bacteriol 172:4529–4535
    [Google Scholar]
  7. Lin R., D’Ari R., Newman E. B. 1992; λplacMu insertions in genes of the leucine regulon: extension of the regulon to genes not regulated by leucine.. J Bacteriol 174:1948–1955
    [Google Scholar]
  8. Maniatis T., Fritsch E. F., Sambrook J. 1982; Molecular Cloning: a Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory..
    [Google Scholar]
  9. Miller J. H. 1972; Experiments in Molecular Genetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory..
    [Google Scholar]
  10. Newman E. B., Lin R. T. 1995; Leucine-responsive regulatory protein, a global regulator of gene expression in E. coli.. Annu Rev Microbiol 49:747–775
    [Google Scholar]
  11. Newman E. B., D’Ari R., Lin R. T. 1992; The leucine-Lrp regulon in E. coli: a global response in search of a raison d’etre.. Cell 68:617–619
    [Google Scholar]
  12. Platko J. V., Willins D. A., Calvo J. M. 1990; The ilvIH operon of Escherichia coli is positively regulated.. J Bacteriol 172:4563–4570
    [Google Scholar]
  13. Su H., Newman E. B. 1991; A novel L-serine deaminase activity in Escherichia coli K-12.. J Bacteriol 173:2473–2480
    [Google Scholar]
  14. Su H., Lang B. F., Newman E. B. 1989; L-serine degradation in Escherichia coli K-12. Cloning and sequencing of the sdaA gene.. J Bacteriol 171:5095–5102
    [Google Scholar]
  15. Tchetina E., Newman E. B. 1994; Identification of Lrpregulated genes by inverse PCR and sequencing: regulation of two mal operons in E. coli by leucine-responsive regulatory protein.. J Bacteriol 177:2679–2683
    [Google Scholar]
  16. Wang Q., Wu J., Friedberg D., Platko J., Calvo J. M. 1994; Regulation of the Escherichia coli lrp gene.. J Bacteriol 176:1831–1839
    [Google Scholar]
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