1887

Abstract

The yeast gene encodes a presumed protein kinase. The gene is essential for manifestation of resistance to the antibiotic polymyxin B. Deletion of enables a null mutant to grow on nonfermentable carbon sources; overexpression of enhances viability of a mutant. Overexpression of also diminishes cellular response to mating pheromone MFα. These results suggest that the and genes affect a common pathway that may communicate with the pheromone response pathway. In addition, disruption of renders cells sensitive to high osmolarity: exposure to 0.9 M-NaCl causes growth arrest, appearance of bizarre morphological forms, and eventual death. A mutation suppressing deletion has been found. That mutation restores full polymyxin B resistance but only partially corrects the osmotic sensitivity defect. These observations indicate that is involved in diverse physiological pathways in yeast.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-138-11-2425
1992-11-01
2019-09-16
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-138-11-2425
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error