Summary: Thermotolerance in is induced by exposing cells to a brief heat shock (42°C for 15 min). This results in resistance to the lethal effect of exposure to a higher temperature (50°C). Mutants defective in the and genes are more sensitive to heat than the wild-type. However, after development of thermotolerance these mutants are like the wild-type in their heat sensitivity. This suggests that thermotolerance is an inducible response capable of protecting cells from the lethal effects of heat, independently of and Thermotolerance does not develop in a mutant. In addition, the mutant is sensitive to heat and HO, but is resistant to UV irradiation. This implies that the heat-shock response includes a mechanism that protects cells from heat and HO, but not from UV.


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