1887

Abstract

Treatment of BGM (African Green Monkey kidney) cells with the calcium antagonist Verapamil resulted in a reduced yield of chlamydial infectious particles. The inhibitory effect was concentration-dependent, the maximal effect being achieved at 200 μM-Verapamil, which produced a 99·99% reduction of infectious particle yield. Electron microscopy showed that control -infected BGM cells contained typical large inclusions in which most of the particles were elementary bodies, whereas Verapamil-treated infected cells contained small inclusions consisting predominantly of reticulate bodies. The findings indicate a possible therapeutic use of this calcium antagonist as an anti-chlamydial drug.

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/content/journal/micro/10.1099/00221287-135-6-1619
1989-06-01
2019-10-14
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-135-6-1619
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