SUMMARY: A mutation, , in the locus of allows appreciable transcription of and and later operons, even though most of the cells are morphologically blocked at stage 0 and the incidence of heat-resistant spores is about 1 per 10 cells. This mutation therefore appears to disengage the genetic control of sporulation from the morphological changes to which it should be connected. and are transcribed independently of one another. However, the products of both operons are needed for the activation of which occurs later. This indicates a convergence of parallel pathways of operon expression. We have also shown that nonsense mutations in (which codes for a sigma factor of RNA polymerase) prevent transcription of ; by contrast, missense mutations in the same gene allow transcription of .


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