Summary: isolates examined in this study elaborated one of two pilus types that were antigenically markedly different. Each pilus type reacted either with SM1, a monoclonal antibody that recognizes an epitope common to all gonococcal pili, or with a polyclonal antiserum raised against meningococcal pili that did not react with SM1, but not both. Total genomic DNA from all isolates analysed, irrespective of pilus type, contained at least one region with extensive homology to a gonococcal probe. Different strains possessed one of several configurations of genomic -homologous segments. Chromosomal rearrangement of -homologous sequences was associated with P to P pilus phase transition in the strains examined. The arrangement of -homologous segments in total genomic DNA from isolated from the blood and cerebro-spinal fluid of the same patient was apparently identical.


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