SUMMARY: Luminol-dependent chemiluminescence was used as a monitor of reactive oxidant generation during phagocytosis of by human neutrophils. Reactive oxidants play a crucial role in the killing of this organism because: () was killed most rapidly when the rate of increase of chemiluminescence was greatest; () neutrophils which had been activated to generate reactive oxidants by re-aeration of anaerobic suspensions killed this bacterium more efficiently than control suspensions; and () neutrophils from a patient with chronic granulomatous disease could neither generate reactive oxidants nor kill .


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