RT Journal Article SR Electronic(1) A1 Edwards, Steven W. A1 Say, Jane E. A1 Hart, C. AnthonyYR 1987 T1 Oxygen-dependent Killing of Staphylococcus aureus by Human Neutrophils JF Microbiology, VO 133 IS 12 SP 3591 OP 3597 DO https://doi.org/10.1099/00221287-133-12-3591 PB Microbiology Society, SN 1465-2080, AB SUMMARY: Luminol-dependent chemiluminescence was used as a monitor of reactive oxidant generation during phagocytosis of Staphylococcus aureus by human neutrophils. Reactive oxidants play a crucial role in the killing of this organism because: (a) S. aureus was killed most rapidly when the rate of increase of chemiluminescence was greatest; (b) neutrophils which had been activated to generate reactive oxidants by re-aeration of anaerobic suspensions killed this bacterium more efficiently than control suspensions; and (c) neutrophils from a patient with chronic granulomatous disease could neither generate reactive oxidants nor kill S. aureus., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-133-12-3591