SUMMARY: pFM739, an R plasmid from that encodes penicillin, streptomycin and sulphonamide resistance, and the enterobacterial IncQ(P-4) plasmid RSF1010, which encodes streptomycin and sulphonamide resistance, were incompatible, and were mobilized by the same conjugative plasmids. Restriction mapping confirmed a high degree of similarity between both R plasmids; pFM739 carried DNA fragments corresponding to the known replication and resistance regions of RSF1010. pFM739 also carried an extra segment with the same restriction map as that described for the β-lactamase-coding region of transposon Tn It is suggested that the R plasmids isolated from commensal sp. could have resulted from transposition of a Tn-like genetic element to an RSF1010-like plasmid, and that they contain deletion derivatives of transposon Tn


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