1887

Abstract

A laboratory-grown strain of , selected , BS4 (agar), is susceptible to complement-mediated killing by fresh human serum but is relatively resistant to killing by human phagocytes. It can be induced to serum resistance by incubation with a small molecular weight fraction of guinea pig serum. The serum-susceptible and induced-resistant forms show differences in pyocin sensitivity tests. This indicates either differences in the structure of their lipopolysaccharides or masking of some determinant(s). The pyocin sensitivity pattern of BS4 (agar) is only slightly different from that of a closely related strain, BSSH, which is more susceptible to killing by human phagocytes.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-130-5-1303
1984-05-01
2021-10-27
Loading full text...

Full text loading...

/deliver/fulltext/micro/130/5/mic-130-5-1303.html?itemId=/content/journal/micro/10.1099/00221287-130-5-1303&mimeType=html&fmt=ahah

References

  1. Blackwell C. C., Young H., Anderson I. 1979; Sensitivity of Neisseria gonorrhoeae to partially purified R-type pyocines and a possible approach to epidemiological typing. Journal of Medical Microbiology 12:321–335
    [Google Scholar]
  2. Blackwell C. C., Kowolik M., Winstanley F. P., Kinane D. F., Weir D. N., Law J. A., Ho Wangchok Y. L., Chok Y. L. 1983; ABO blood group and susceptibility to gonoccal infection. I. Factors affecting phagocytosis of Neisseria gonorrhoeae. Journal of Clinical and laboratory Immunology 4:173–178
    [Google Scholar]
  3. Brooks G. F., Gotschlich E. C., Holmes K. K., Sawyer W, Young F. E. 1978 Immunology of Neisseria gonorrhoeae. Washington, DC: American Society for Microbiology;
    [Google Scholar]
  4. Guymon L. F., Esser M., Shaffer W. M. 1982; Pyocin-resistant lipopolysaccharide mutants of Neisseria gonorrhoeae: alterations in sensitivity to normal human serum and polymyxin B. Infection and Immunity 36:541–547
    [Google Scholar]
  5. Demarco De Hormaeche R., Thornley M. J., Glauert A. M. 1978; Demonstration by light and electron microscopy of capsules on gonococci recently grown in vivo. Journal of General Microbiology 106:81–91
    [Google Scholar]
  6. James J. F., Zurlinden E., Lammel C. J., Brooks G. F. 1982; Relation of protein I and colonial opacity to serum killing of Neisseria gonorrhoeae. Journal of Infectious Diseases 145:37–44
    [Google Scholar]
  7. Kageyama M. 1975; Bacteriocins and bacteriophages in Pseudomonas aeruginosa. In Microbial Drug Resistance: Report of the International Symposium on Bacterial Resistance pp. 291–309 Edited by Mitsuhasi S., Hashimoto H. Tokyo: University of Tokyo Press;
    [Google Scholar]
  8. Lambden P. R., Heckels J. E., James L. T., Watt P. J. 1979; Variations in surface proteins associated with virulence properties in opacity types of Neisseria gonorrhoeae. Journal of General Microbiology 114:305–312
    [Google Scholar]
  9. Martin P. M. V, Patel P. V., Parsons N. J., Smith H. 1981; Induction of phenotypically determined resistance of Neisseria gonorrhoeae to human serum by factors in human serum. Journal of General Microbiology 127:213–217
    [Google Scholar]
  10. Meadow P. M., Wells P. L. 1978; Receptor sites for R-type pyocins and bacteriophage E79 in the core part of the lipopolysaccharide(s) of Pseudomonas aeruginosa PAC1. Journal of General Microbiology 108:339–343
    [Google Scholar]
  11. Morse S. A., Vaughan P., Johnson D., Iglewski B. H. 1976; Inhibition of Neisseria gonorrhoeae by a bacteriocin from Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 10:354–362
    [Google Scholar]
  12. Parsons N. J., Kwaasi A. A. A, Turner J. A., Veale D. R., Perera V. Y., Penn C. W., Smith H. 1981; Investigation of the determinants of the survival of Neisseria gonorrhoeae within human polymorphonuclear phagocytes. Journal of General Microbiology 127:103–112
    [Google Scholar]
  13. Parsons N. J., Kwaasi A. A. A, Perera V. Y., Patel P. V., Martin P. M. V, Smith H. 1982; Outer membrane proteins of Neisseria gonorrhoeaeassociated with survival within human polymorphonuclear phagocytes. Journal of General Microbiology 128:3077–3081
    [Google Scholar]
  14. Penn C. W., Sen D., Veale D. R., Witt K., Parsons N. J., Smith H. 1976; Morphological, biological and antigenic properties of Neisseria gonorrhoeae adapted to growth in guinea pig subcutaneous chambers. Journal of General Microbiology 97:35–43
    [Google Scholar]
  15. Penn C. W., Veale D. R., Smith H. 1977; Selection from gonococci grown in vitro of a colony type with some virulence properties of organisms adapted in vivo. Journal of General Microbiology 100:147–158
    [Google Scholar]
  16. Schneider H., Griffiss J. M., Williams G. D., Pier G. B. 1982; Immunological basis of serum resistance of Neisseria gonorrhoeae. Journal of General Microbiology 128:13–20
    [Google Scholar]
  17. Sidberry H. D., Sadoff J. C. 1977; Pyocin sensitivity of Neisseria gonorrhoeae and its feasibility as an epidemiological tool. Infection and Immunity 15:628–637
    [Google Scholar]
  18. Smith H. 1983; The elusive determinants of bacterial interference with non-specific host defences. Philosophical Transactions of the Royal Society B303:99–113
    [Google Scholar]
  19. Veale D. R., Penn C. W., Parsons N. J., Smith H. 1980; Preliminary studies of a factor in guinea pig serum which induces serum resistance in Neisseria gonorrhoeae. Society for General Microbiology Quarterly 7:188
    [Google Scholar]
  20. Veale D. R., Penn C. W., Smith H. 1981; Factors affecting the induction of phenotypically determined serum resistance of Neisseria gonorrhoeae grown in media containing serum or its diffusible components. Journal of General Microbiology 122:239–245
    [Google Scholar]
  21. Wlnstanley F. P., Blackwell C. C., Weir D. M., Kinane D. F. 1983; Blood groups and susceptibility to gonococcal infection. II. The relationship of lipopolysaccharide type to gonococcal sensitivity to the bactericidal activity of normal human serum. Journal of Clinical and Laboratory Immunology 11:27–32
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-130-5-1303
Loading
/content/journal/micro/10.1099/00221287-130-5-1303
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error