1887

Abstract

SUMMARY: Appropriate quantities of sodium metaperiodate injected into hen eggs inhibited the development of full infectivity by some strains of influenza virus, i.e, ‘incomplete’ virus was produced; with other strains of virus the same quantities of metaperiodate inhibited haemagglutinin production. Metaperiodate in a dose which of itself did not inhibit haemagglutinin production by two strains of influenza virus enhanced the inhibitory action of heated influenza virus on haemagglutinin production by these strains. Both sodium metaperiodate and heated influenza virus inhibited the production of influenza virus filaments more than that of spheres. It is suggested that both metaperiodate and heated influenza virus act on a common substrate which is required for the development of both viral agglutinin and full virus infectivity.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-13-2-330
1955-10-01
2024-10-10
Loading full text...

Full text loading...

/deliver/fulltext/micro/13/2/mic-13-2-330.html?itemId=/content/journal/micro/10.1099/00221287-13-2-330&mimeType=html&fmt=ahah

References

  1. Ackermann W.W., Massaab H.F. 1954; Growth characteristics of influenza virus. Biochemical differentiation of stages of development. J. exp. Med. 100:329
    [Google Scholar]
  2. Dawson I.M., Elford W.J. 1949; The investigation of influenza and related viruses in the electron microscope, by a new technique. J. gen. Microbiol. 3:298
    [Google Scholar]
  3. Depoux R., Isaacs A. 1954; Effect of inhibitors on interference between influenza and vaccinia viruses. Brit. J. exp. Path. 35:419
    [Google Scholar]
  4. Donald H.B., Isaacs A. 1954; Some properties of virus filaments shown by electron microscopic particle counts. J. gen. Microbiol. 11:325
    [Google Scholar]
  5. Edney M., Isaacs A. 1950; Interference between inactive and active influenza viruses in the chick embryo. 3. Inhibitor of virus haemagglutination in the chorio-allantoic membrane. Aust. J. exp. Biol. med. Sci. 28:603
    [Google Scholar]
  6. Fazekas De St Groth S., Graham D.M. 1954a; Artificial production of incomplete influenza virus. Nature; Lond.: 173637
    [Google Scholar]
  7. Fazekas De St Groth S., Graham D.M. 1954b; The production of incomplete virus particles among influenza strains: experiments in eggs. Brit. J. exp. Path. 35:60
    [Google Scholar]
  8. Henle W. 1953 In Advances in Virus Research 1 p. 142 New York: Academic Press Inc.;
    [Google Scholar]
  9. Henle W., Henle G. 1944; Interference between inactive and active viruses of influenza. I. The incidental occurrence and artificial induction of the phenomenon. Amer. J. med. Sci. 207:705
    [Google Scholar]
  10. Horsfall F. Jun. 1954; On the reproduction of influenza virus. Quantitative studies with procedures which enumerate infective and haemagglutinating virus particles. J. exp. Med. 100:135
    [Google Scholar]
  11. Isaacs A., Edney M. 1951; Interference between inactive and active influenza viruses in the chick embryo. 5. The behaviour of different strains of challenge virus. Aust. J. exp. Biol. med. Sci. 29:169
    [Google Scholar]
  12. Liu O.C., Henle W. 1951; Studies on host-virus interactions in the chick embryo-influenza virus system. 4. The role of inhibitors of haemagglutination in the evaluation of viral multiplication. J. exp. Med. 94:269
    [Google Scholar]
  13. Magnus P., Von. 1946; Studies on interference in experimental influenza. 1. Biological observations. Arkiv. Kemi Min. Geol. 24B:1
    [Google Scholar]
  14. Magnus P., Von. 1954; . In Advances in Virus Research 2 p. 59 New York: Academic Press Inc.;
    [Google Scholar]
  15. Reed J.L., Muench H. 1938; A simple method of estimating fifty per cent endpoints. Amer. J. Hyg. 27:493
    [Google Scholar]
  16. Schlesinger R.W. 1953; Multiplication and enzymic activity of influenza virus in infected tissues. In Interaction of viruses and cells. Symp. 6th Congr. int. Microbiol p. 36
    [Google Scholar]
/content/journal/micro/10.1099/00221287-13-2-330
Loading
/content/journal/micro/10.1099/00221287-13-2-330
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error