Summary: Appropriate quantities of sodium metaperiodate injected into hen eggs inhibited the development of full infectivity by some strains of influenza virus, i.e, ‘incomplete’ virus was produced; with other strains of virus the same quantities of metaperiodate inhibited haemagglutinin production. Metaperiodate in a dose which of itself did not inhibit haemagglutinin production by two strains of influenza virus enhanced the inhibitory action of heated influenza virus on haemagglutinin production by these strains. Both sodium metaperiodate and heated influenza virus inhibited the production of influenza virus filaments more than that of spheres. It is suggested that both metaperiodate and heated influenza virus act on a common substrate which is required for the development of both viral agglutinin and full virus infectivity.


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