Summary: The bactericidal activities of mixtures of various chemotherapeutic drugs were tested against the H37Rv strain of when growing in Tween albumin medium. Oxytetracycline (terramycin) antagonized the bactericidal activities of streptomycin, isoniazid and viomycin, whereas -aminosalicylic acid (PAS) was slightly synergistic or did not influence their activities. Mixtures of viomycin and streptomycin were slightly less bactericidal than streptomycin alone, but more bactericidal than viomycin alone. Viomycin acted synergistically with isoniazid, and with isoniazid + streptomycin. The emergence of strains resistant to streptomycin, isoniazid or viomycin was not prevented in the cultures by the presence of oxytetracycline, probably because of its rapid inactivation. Drug resistance emerged in dual mixtures which included PAS, where the concentrations of streptomycin, isoniazid or PAS were low, but not when these concentrations were high. Resistant strains did not emerge in cultures containing viomycin + streptomycin or viomycin + isoniazid.


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