1887

Abstract

Summary: The bactericidal activities of mixtures of various chemotherapeutic drugs were tested against the H37Rv strain of when growing in Tween albumin medium. Oxytetracycline (terramycin) antagonized the bactericidal activities of streptomycin, isoniazid and viomycin, whereas -aminosalicylic acid (PAS) was slightly synergistic or did not influence their activities. Mixtures of viomycin and streptomycin were slightly less bactericidal than streptomycin alone, but more bactericidal than viomycin alone. Viomycin acted synergistically with isoniazid, and with isoniazid + streptomycin. The emergence of strains resistant to streptomycin, isoniazid or viomycin was not prevented in the cultures by the presence of oxytetracycline, probably because of its rapid inactivation. Drug resistance emerged in dual mixtures which included PAS, where the concentrations of streptomycin, isoniazid or PAS were low, but not when these concentrations were high. Resistant strains did not emerge in cultures containing viomycin + streptomycin or viomycin + isoniazid.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-13-1-176
1955-08-01
2024-05-13
Loading full text...

Full text loading...

/deliver/fulltext/micro/13/1/mic-13-1-176.html?itemId=/content/journal/micro/10.1099/00221287-13-1-176&mimeType=html&fmt=ahah

References

  1. Bryson V., Demerec M. 1950; Patterns of resistance to antimicrobial agents. Ann. N.Y. Acad. Sci 53:283
    [Google Scholar]
  2. Des Autels E. J. 1953; The effect of terramycin in delaying the emergence of bacillary resistance to streptomycin. U.S. Veterans Administration. Trans. 12th Conf. Chemotherapy Tuberculosis, Washington, D.C p. 304
    [Google Scholar]
  3. Gunnison J. B., Coleman V. R., Jawetz E. 1950; Interference of aureomycin and terramycin with action of penicillin in vitro. Proc. Soc. exp. Biol., N.Y 75549
    [Google Scholar]
  4. Hackney R. L., King E. Q., Marshall E. E., Harden K., Payne H. M. 1953; Clinical observations on viomycin sulphate in the treatment of tuberculosis. Dis. Chest 24:591
    [Google Scholar]
  5. Hobby G.I.. 1953; Viomycin. Summary of a four-year evaluation. U.S. Veterans Administration. Trans. 12th Conf. Chemotherapy Tuberculosis, Washington, D.C p. 300
    [Google Scholar]
  6. Hobby G. L., Lenert T. F., Donikian M., Pikula D. 1951a; The activity of viomycin against Mycobacterium tuberculosis and other microorganisms in vitro and in vivo. Amer. Rev. Tuberc 63:17
    [Google Scholar]
  7. Hobby G. L., Lenert T. F., Donikian M., Pikula D. 1951b; The tuberculostatic activity of terramycin. Amer. Rev. Tuberc 63:434
    [Google Scholar]
  8. Jawetz E., Gunnison J. B., Speck R. S. 1951; Studies on antibiotic synergism and antagonism: interference of aureomycin, chloramphenicol and terramycin with action of streptomycin. Amer. J. med. Sci 222:404
    [Google Scholar]
  9. Karlson A. G., Gainer J. H. 1951; The effect of viomycin in tuberculosis of guinea-pigs including in vitro effects against tubercle bacilli resistant to other drugs. Amer. Rev. Tuberc 63:36
    [Google Scholar]
  10. Mackaness G. B., Smith N. 1953; The bactericidal action of isoniazid, streptomycin and terramycin on extracellular and intracellular tubercle bacilli. Amer. Rev. Tuberc 67:322
    [Google Scholar]
  11. Medical Research Council 1953; Laboratory techniques for the determination of sensitivity of tubercle bacilli to isoniazid, streptomycin and PAS. Lancet ii213
    [Google Scholar]
  12. Middlebrook G., Yegian D. 1946; Certain effects of streptomycin on mycobacteria in vitro. Amer. Rev. Tuberc 54:553
    [Google Scholar]
  13. Miller F. L., Sands J. H., Gregory L. J., Hightower J. A., Weisser O. L., Tempel C. W. 1954; Daily oxytetracycline (terramycin) and intermittent streptomycin in the treatment of pulmonary tuberculosis. Amer. Rev. Tuberc 69:58
    [Google Scholar]
  14. Miller F. L., Sands J. H., Walker R., Dye W. E., Tempel C. W. 1952; Combined daily terramycin and intermittent streptomycin in the treatment of pulmonary tuberculosis. Amer. Rev. Tuberc 66:534
    [Google Scholar]
  15. Mitchison D. A. 1954; Problems of drug resistance. Brit. med. Bull 10:115
    [Google Scholar]
  16. Pfefer L. M., Hughes F. J., Dye W. E. 1952; Terramycin in the treatment of pulmonary tuberculosis: A pilot study. Dis. Chest 21:123
    [Google Scholar]
  17. Pitts F. W., O’Dell E. T., Fitzpatrick M. J., Dye W. E., Hughes F. J., Tempel C. W. 1953; Intermittent viomycin therapy in pulmonary tuberculosis. Dis. Chest 23:241
    [Google Scholar]
  18. Regna P. P., Solomons I. A. 1950; Chemical and physical properties of terramycin. Ann. N.Y. Acad. Sci 53:229
    [Google Scholar]
  19. Rist N. 1953; The application to clinical practice of the laboratory experience with combinations of antituberculosis drugs. Bull. Un. int. Tuberc 23:416
    [Google Scholar]
  20. Rothstein E., Johnson M. P. 1954; Streptomycin and oxytetracycline (terramycin) in the treatment of pulmonary tuberculosis. Amer. Rev. Tuberc 69:65
    [Google Scholar]
  21. Schaeffer W. B. 1954; The effect of isoniazid on growing and resting tubercle bacilli. Amer. Rev. Tuberc 69:125
    [Google Scholar]
  22. Sievers O. 1949; Sensitivity of tubercle bacillus. Lancet i:798
    [Google Scholar]
  23. Singh B. 1954 The synergistic and antagonistic action of chemotherapeutic agents on the tubercle bacillus in vitro Ph.D. thesis University of London:
    [Google Scholar]
  24. Singh B., Mitchison D. A. 1954; Bactericidal activity of streptomycin and isoniazid against tubercle bacilli. Brit. med. J i:130
    [Google Scholar]
  25. Singh B., Mitchison D. A. 1955; Bactericidal activity of streptomycin and isoniazid with para-aminosalicylic acid against Mycobacterium tuberculosis. J. gen. Microbiol 12:76
    [Google Scholar]
  26. Soderholm B. 1952; Clinical experiments with terramycin in the treatment of pulmonary tuberculosis. Acta. tuberc. scand 27:109
    [Google Scholar]
  27. Steenken W., Wolinsky E. 1951; Viomycin in experimental tuberculosis. Amer. Rev. Tuberc 63:30
    [Google Scholar]
  28. Stewart S., Turnbull F. W. A., Crofton J. W. 1954; The use of oxytetracycline in preventing or delaying isoniazid resistance in pulmonary tuberculosis. Brit. med. J ii:1508
    [Google Scholar]
  29. Tison F. 1950; Dissociation des pouvoirs ‘bacteriostatique’ et ‘bactericide’ de la streptomycine in vitro sur le bacille de Koch. Ann. Inst. Pasteur 79:100
    [Google Scholar]
  30. Tucker W. B. 1954; Re-treatment of advanced pulmonary tuberculosis with viomycin. Amer. Rev. Tuberc 70:812
    [Google Scholar]
  31. Werner C. A., Tompsett R., Muschenheim C., McDermott W. 1951; The toxicity of viomycin in humans. Amer. Rev. Tuberc 63:49
    [Google Scholar]
  32. Youmans G. P., Youmans A. S. 1951; The effect of viomycin in mtro and in vivo on Mycobacterium tuberculosis. Amer. Rev. Tuberc 63:25
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-13-1-176
Loading
/content/journal/micro/10.1099/00221287-13-1-176
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error