1887

Abstract

SUMMARY: Transient exposure of mycelia from to the cytidine analogue 5-azacytidine, at concentrations which do not affect the growth rate of the fungus on nearly minimal media, result in a dose-dependent, heritable change in the timing of the conidiation programme as well as heritable over-production of adaptive enzymes (glycosidases and phosphatases) and modification in the control properties of acid phosphatase. These heritable changes are induced by 5-azacytidine in a non-random way since the new phenotypes are exhibited not only by isolated clones but also by mixed populations of mycelia several life cycles (thousands of mitoses) after exposure to the drug.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-129-8-2585
1983-08-01
2019-10-23
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-129-8-2585
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error