SUMMARY: DNA repair and genetic recombination have been studied in mutants of in which expression of inducible, SOS repair activities was altered by additional mutations either in or and appeared to act additively to increase sensitivity to UV irradiation and to reduce recombination proficiency. The defect was suppressed in strains carrying the allele of but not in strains carrying mutations that increased synthesis of protein or which directly inactivated repressor. These and other data are interpreted to suggest that the defect is related to a reduced activity of protein. The implications of these findings are discussed in relation to the control of SOS activities and cell division during normal growth.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error