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Abstract
Four mutants of Escherichia coli K12 were isolated on the basis of their sensitivity to pH 5·4. Under non-permissive conditions their growth was reversibly inhibited. At pH 7·0 these mutants showed a highly pleiotropic phenotype, which included altered phage and detergent sensitivities and leakage of periplasmic proteins. The findings suggest a defect in the outer membrane, perhaps in lipopolysaccharide. Two mutants mapped in or near the rfa locus, while the other two were remote from this region.
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© Society for General Microbiology 1982