1887

Abstract

Exogenous thymine was found to be taken up very slowly by in comparison to other pyrimidines, and most of it was catabolized by the cell. The existence of a functional, although inefficient, thymine salvage pathway was demonstrated and this pathway operated more effectively when thymidine nucleotide biosynthesis was inhibited by trimethoprim or methotrexate. The mechanism of thymine salvage by appears to be different from that of and as thymidine was not incorporated into the DNA. Like lacked thymidine phosphorylase activity. Unsuccessful attempts were made to isolate thymine auxotrophs.

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1982-07-01
2021-05-12
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