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The turimycin-producing Streptomyces hygroscopicus strain JA6599/NG60-93 (Tur+Amy+) and strain CCl, which is unable to produce antibiotic and aerial mycelium (Tur−Amy−), were compared with respect to their mycelial enzyme activities and cellular lipid composition. Changed activities of six enzymes of intermediary metabolism during submerged growth of strain CCl on chemically defined medium attest to alterations of the life cycle. In addition, strain CCl contained decreased amounts of 12-methyltetradecanoic acid in relation to 14-methylpentadecanoic acid (isopalmitic acid) and displayed a quantitatively altered phospholipid composition.
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