SUMMARY: Thiabendazole and cambendazole induced mitotic arrest and isogenic diploid formation through chromosome doubling in amoebae of the cellular slime mould grown either axenically or in a bacterial suspension. The effect of nocodazole on axenically grown cells was similar to that of thiabendazole and cambendazole, but with cells grown on bacteria nocodazole was a much less effective inducer of mitotic arrest and did not lead to isogenic diploid formation. Benomyl, the active ingredient of ben late, had little or no effect on the induction of mitotic arrest and was a poor inducer of isogenic diploids in cells grown either axenically or on bacteria. All four benzimidazole derivatives were effective in haploidizing pre-existing diploids.


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