1887

Abstract

Regulation of the cross-pathway type was found in Ornithine carbamoyltransferase, a biosynthetic enzyme of the arginine pathway, is derepressed as a result of deprivation not only of arginine but also of histidine, proline and tryptophan. Cross-pathway regulation operates in the mutant in which the ornithine carbamoyl-transferase level is insensitive to arginine. The spectrum of the amino acids involved in this type of regulation seems to be different from those described for other fungi.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-116-2-335
1980-02-01
2024-10-10
Loading full text...

Full text loading...

/deliver/fulltext/micro/116/2/mic-116-2-335.html?itemId=/content/journal/micro/10.1099/00221287-116-2-335&mimeType=html&fmt=ahah

References

  1. Bartnik E., Guzewska J., Kumczuk J., Piotrow-SKA M., Weglenski P. 1977; Regulation of arginine catabolism inAspergillus nidulans. In Genetics and Physiology of Aspergillus pp. 243–254 Smith J. E., Pateman J. A. Edited by London: Academic Press;
    [Google Scholar]
  2. Carsiotis M., Jones R. F., Wesseling A. C. 1974; Cross-pathway regulation:histidine-mediated control of histidine, tryptophan and arginine biosynthetic enzymes inNeurospora crassa. Journal of Bacteriology 119:893–898
    [Google Scholar]
  3. Cove D. J. 1966; The induction and repression of nitrate reductase in the fungusAspergillus nidulans. Biochimica et biophysica acta 113:51–56
    [Google Scholar]
  4. Cybis J., Piotrowska M., Weglenski P. 1970; Control of ornithine transcarbamylase formation inAspergillus nidulans. Bulletin de l’Academie polonaise des sciences, Serie des Sciences biologi- ques 18:669–672
    [Google Scholar]
  5. Cybis J., Piotrowska M., Weglenski P. 1972; Genetic control of the arginine pathways inAspergillus nidulans. Common regulation of anabolism and catabolism. Molecular and General Genetics 118:273–277
    [Google Scholar]
  6. Delforge J., Messenguy F., Wiame J. M. 1975; The regulation of arginine biosynthesis inSaccharomyces cerevisiae. The specificity ofargRr mutations and the general control of amino acid biosynthesis. European Journal of Biochemistry 57:231–239
    [Google Scholar]
  7. Schurch A., Miozzari J., Hütter R. 1974; Regulation of tryptophan biosynthesis inSaccharomyces cerevisiae: mode of action of 5- methyl-tryptophan and 5-methyl-tryptophan-sensitive mutants. Journal of Bacteriology 117:1131–1140
    [Google Scholar]
  8. Spector L., Jones M. E., Lipmann F. 1957; Carbamyl phosphate. Methods in Enzymology 3:643–655
    [Google Scholar]
  9. Van Pilsum J. F., Martin R. P., Kito E., Hess J. 1956; Determination of creatine, creatinine, arginine, guanidoacetic acid, guanidine and methylguanidine in biological fluids. Journal of Biological Chemistry 222:225–236
    [Google Scholar]
  10. Woltner M., Yep D., Messenguy F., Fink G. R. 1975; Integration of aminoacid biosynthesis into the cell cycle ofSaccharomyces cerevisiae. Journal of Molecular Biology 90:273–290
    [Google Scholar]
/content/journal/micro/10.1099/00221287-116-2-335
Loading
/content/journal/micro/10.1099/00221287-116-2-335
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error