1887

Abstract

Butirosin, an aminoglycoside antibiotic, is produced by B-3312. Experiments using recombined ribosomal and supernatant fractions from this strain and from KM have shown that the ribosomes of both are sensitive to butirosin. The aminoglycoside 3′-phosphotransferase present in modifies butirosin and neomycin but confers resistance only to the former . The phosphotransferase does not modify a detectable amount of extracellular butirosin while mediating resistance to the antibiotic. , however, the enzyme appears to protect against inhibition by butirosin by inactivating the bulk of the antibiotic in the system. An extrachromosomal element of unknown function has been detected in .

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/content/journal/micro/10.1099/00221287-115-2-385
1979-12-01
2021-10-28
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