Summary: Butirosin, an aminoglycoside antibiotic, is produced by B-3312. Experiments using recombined ribosomal and supernatant fractions from this strain and from KM have shown that the ribosomes of both are sensitive to butirosin. The aminoglycoside 3'-phosphotransferase present in modifies butirosin and neomycin but confers resistance only to the former . The phosphotransferase does not modify a detectable amount of extracellular butirosin while mediating resistance to the antibiotic. , however, the enzyme appears to protect against inhibition by butirosin by inactivating the bulk of the antibiotic in the system. An extrachromosomal element of unknown function has been detected in .


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