1887

Abstract

The effect of pneumonia induced by in mice on the resistance of the lung to additional bacterial infection was examined. The effect of pneumonia induced by Sendai virus on the resistance of mice to was also investigated and compared with the effect of Sendai virus on resistance to . Sendai virus infection decreased subsequent resistance to in proportion to the virus dose. Decreased resistance to subsequent and infection was greatest at about the same time after inoculation of virus and was related to virus-induced lesions. Besides affecting the resistance of mice to subsequent mycoplasma infection, Sendai virus could enhance an existing mycoplasma infection. Pneumonia induced by did not decrease resistance to subsequent bacterial infection. The mechanism whereby Sendai virus decreases host resistance is therefore similar for bacteria and mycoplasmas, but pneumonia induced by mycoplasmas does not have the same effect.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-109-1-79
1978-11-01
2024-12-09
Loading full text...

Full text loading...

/deliver/fulltext/micro/109/1/mic-109-1-79.html?itemId=/content/journal/micro/10.1099/00221287-109-1-79&mimeType=html&fmt=ahah

References

  1. Adler H. E., McMartin D. A., Ortmayer H. 1962; The effect of infectious bronchitis virus on chickens infected with Mycoplasma gallisepticum . Avian Diseases 6:267–274
    [Google Scholar]
  2. Brennan P. C., Fritz T. E., Flynn R. J. 1969; Role of Pasteurella pneumotropica and Mycoplasma pulmonis in murine pneumonia. Journal of Bacteriology 97:337–349
    [Google Scholar]
  3. Cole B. C., Overall J. C., Lombardi P. S., Glasgow L. A. 1976; Induction of interferon in ovine and human lymphocyte culture by mycoplasmas. Infection and Immunity 14:88–94
    [Google Scholar]
  4. Degre M., Glasgow L. A. 1968; Synergistic effect of viral-bacterial infection. I. Combined infection of the respiratory tract in mice with parainfluenza virus and Haemophilus influenzae . Journal of Infectious Diseases 118:449–462
    [Google Scholar]
  5. Dunlop W. R., Parke G., Strout R. G., Smith S. C. 1964; The effect of sequence of infection on complex respiratory disease. Avian Diseases 8:321–327
    [Google Scholar]
  6. Eaton P. 1974; A laboratory model for respiratory disease investigation and its application to variations in climatic environment. Ph.D. thesis, University of Edinburgh
    [Google Scholar]
  7. Fabricant J. 1969; Avian mycoplasmas. The Mycoplasmatales and the l-phase of Bacteria621–641 Hayflick L. Amsterdam: North Holland Publishing Co;
    [Google Scholar]
  8. Gourlay R. N., Mackenzie A., Cooper J. E. 1970; Studies of the microbiology and pathology of pneumonic lungs of calves. Journal of Comparative Pathology 80:575–584
    [Google Scholar]
  9. Harford C. G., Leidler V., Hara M. 1949; Effect of the lesion due to influenza virus on the resistance of mice to inhaled pneumococci. Journal of Experimental Medicine 89:53–68
    [Google Scholar]
  10. Henderson D. W. 1964; Mixed populations in vivo and in vitro . Symposia of the Society for General Microbiology 14:241–256
    [Google Scholar]
  11. Jakab G. J. 1975; Suppression of pulmonary antibacterial activity following Sendai virus infection in mice: dependence on virus dose. Archives of Virology 48:385–390
    [Google Scholar]
  12. Jakab G. J., Dick E. C. 1973; Synergistic effect of viral-bacterial infection: combined infection of the murine respiratory tract with Sendai virus and Pasteurella pneumotropica . Infection and Immunity 8:762–768
    [Google Scholar]
  13. Jakab G. J., Green G. M. 1972; The effect of Sendai virus infection on bactericidal and transport mechanisms of the murine lung. Journal of Clinical Investigation 51:1989–1998
    [Google Scholar]
  14. Jakab G. J., Green G. M. 1973; Effect of hypersensitivity pneumonitis on the pulmonary defense mechanisms of guineapig lungs. Infection and Immunity 7:39–45
    [Google Scholar]
  15. Liu C., Jayanetra P., Voth D. W., Muangmanee L., Cho C. T. 1972; Potentiating effect of Mycoplasma pneumoniae infection on the development of pneumococcal septicemia in hamsters. Journal of Infectious Diseases 125:603–612
    [Google Scholar]
  16. Robinson T. W. E., Cureton R. J. R., Heath R. B. 1968; The pathogenesis of Sendai virus infection in the mouse lung. Journal of Medical Microbiology 1:89–95
    [Google Scholar]
  17. Shaw C., Stitt J. M., Cowan S. T. 1951; Staphylococci and their classification. Journal of General Microbiology 5:1010–1023
    [Google Scholar]
  18. Taylor G., Howard C. J., Gourlay R. N. 1977; Protective effect of vaccines on Mycoplasma pulmonis induced respiratory disease of mice. Infection and Immunity 16:422–431
    [Google Scholar]
/content/journal/micro/10.1099/00221287-109-1-79
Loading
/content/journal/micro/10.1099/00221287-109-1-79
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error